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余兆松

余兆松

職稱:教授

研究室名稱:訊息傳遞與蛋白質體學研究室

最高學歷Ph.D.

學校/國家:國立清華大學/中華民國

分機號碼5171

電子郵件帳號 yusong@mail.cgu.edu.tw

個人網頁網址:http://yusong1.wix.com/jsyu-lab

研究室現有: 博士後研究員  1

博士班研究生  4

碩士班研究生 1

專任研究助理  3 

大學部專題生  4

updated at 2016/8/1

研究方向

(1)以蛋白質體學技術平台找尋與驗證癌症生物標誌及分析癌症之異常分子調節機轉:

癌症為人類主要死因之一。大部份癌症被診斷時皆為中晚期,是癌症死亡率居高不下的主因。除了養成健康生活習慣外,早期診斷與治療是對抗癌症的唯一有效方法。雖然有效的癌症標誌並不多,抽取體液(血液、尿液、唾液等)檢查其中可能的癌症生物標誌(biomarker)仍是最方便的初步篩檢方法。因此找尋新穎且更為有效的體液生物標誌是對早期診斷癌症非常重要的課題。以質譜學為基礎之蛋白質體學為近年來新興學門,由於具備高靈敏度、高精確度與高通量之特性,被學界寄予厚望可以用來系統性分析(包括定性與定量)癌症相關樣品中蛋白質,藉以找尋與驗證具高應用價值的癌症生物標誌。敝人實驗室與本校多位同仁合作,共同建立長庚大學蛋白質體學核心實驗室,發展多種蛋白質體相關定性與定量分析技術平台,分別利用三種生物材料(癌症病患癌細)找尋癌症生物標誌及分析癌症之異常分子調節機轉。長期目標在於發展出可實際應用於臨床偵測早期癌症及其復發的體液生物標誌,同時發展可快速方便檢驗這些生物標誌的方法。

(2)蛋白激脢PAKGSK-3之生理功能及調控機制:

可逆的蛋白質的磷酸化-脫磷酸化作用是一種調節細胞諸多生理功能的重要機制。蛋白激脢酵素群(protein kinases)負責蛋白質的磷酸化,而蛋白質脫磷酸化酵素(protein phosphatases)則負責脫磷酸化作用。生物體透過這兩類酵素活性在體內所達成的特定平衡狀態,來調節體內各式各樣的關鍵酵素和蛋白的磷酸化程度,迅速而有效的改變它們的構形與活性,進而對外在刺激作出適當反應。因此,這兩類酵素群在生物體內訊息傳遞作用機制中扮演相當重要角色。本實驗室目前針對兩種蛋白激脢 -- p21-activated kinase 2 (PAK2)glycogen synthase kinase-3 (GSK-3)分別在細胞凋亡(apoptosis)及癌化過程中可能扮演之生理功能角色及調控機制作深入探討。研究重點在於利用蛋白質體學方法找尋此兩種蛋白激脢新穎的結合分與下游受質。

(3)光照療法對癌細胞的影響-細胞功能變化與分子調節機制:

光照療法(photodynamic therapy, PDT )屬於光化療法的一種,這種療法已通過許多國家包括美國之衛生藥物檢驗相關單位核可,用來治療部分癌症。新陳代謝速率較高的組織(特別是腫瘤組織)對光敏劑(photosensitizer)的吸收能力較好;光照療法即是利用光敏劑此一特性,利用特定波長光線對已經吸收光敏劑之癌細胞組織照射,由於光敏劑吸收特殊波長光能後,會將能量轉換給組織內氧分子,促使高能含氧活化物(reactive oxygen species, ROS)生成,隨後引發細胞中一連串的訊號傳遞,進而導致癌細胞死亡,而達到治療效果。本實驗室曾分析人類皮膚癌A431細胞經過Rose Bengal (一種光敏劑)-PDT處理後,所引發的細胞凋亡訊息傳遞,目前正進一步探討臨床光照療法對癌細胞影響之分子作用機轉。我們使用臨床用藥Photofrin®及氦氖雷射對癌細胞進行PDT處理,發現Photofrin®可以分佈在癌細胞內部同的位置,而隨著分佈的位置不同,PDT所引發的死亡型態與機制亦不相同,其詳細分子機制正在探討中。

研究室特色

實驗室以累積多年之蛋白質酵素分離純化鑑定經驗,過去十多年中投入並成功研發以質譜學為基礎之多種蛋白質體相關定性與定量分析技術。利用這些強大效能蛋白質體分析工具,我們可以重新擴大研究檢視各種細胞內關鍵訊息傳導路徑、發現新穎蛋白質交互作用及分析各種蛋白質後轉譯修飾作用,這些可能性大幅提升了細胞生物學領域研究的廣度與深度。另一方面,藉由完善建立之蛋白質體分析工具,我們同時與臨床醫師合作投入系統性分析癌症病患樣本與正常人樣本的差異,希望發展出可實際應用於臨床偵測早期癌症及其復發的體液生物標誌,同時發展可快速方便檢驗這些生物標誌的方法。

研究內容生動活潑,蘊藏無限可能性應是本研究室最大特色。歡迎對基礎醫學研究充滿熱誠之同學加入我們的研究團隊。

 

 

最近五年所發表論文( #相關研究代表性著作)*corresponding author

 

1.      #Hsu R-M, Tsai M-H, Hsieh Y-J, Lyu P-C, Yu J-S* (2010) Identification of MYO18A as a novel interacting partner of PAK2/bPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol. Biol. Cell 21(2), 287–301. [PubMed]

2.      #Wu C-C, Hsu C-W, Chen C-D, Yu C-J, Chang K-P, Dai D-I, Liu H-P, Su W-H, Chang Y-S, Yu J-S* (2010) Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol. Cell. Proteomics 2010 Jun; 9(6), 1100-1117. [PubMed]

3.      Kao S-H, Hsu T-C, Yu J-S, Chen J-T, Li S-L, Lai W-X, Tzang B-S* (2010) Proteomic analysis for the anti-apoptotic effects of cystamine on apoptosis-prone macrophage. J. Cell. Biochem. 2010 Jun 1; 110(3):660–670. [PubMed]

4.      Chen J-S*, Chen K-T, Fan W-C, Yu J-S, Chang Y-S, Chan E-C* (2010) Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer. Clin. Chem. Lab. Med. 2010 May; 48(5):719-25. [PubMed]

5.      Zhai H-L*, Chang Y-T, Wu C-C, Yu J-S* (2010) An approach to the elimination of inter-individual variability in tumor detection. Analyst 2010 May; 135, 875-879. [PubMed]

6.      #Chang K-P, Wu C-C, Chen H-C, Chen S-J, Peng P-H, Tsang N-M, Lee L-Y, Liu S-C, Liang Y, Lee, Y-S, Hao S-P, Chang Y-S, Yu J-S* (2010) Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: Potential usage of cystatin A for predicting nodal stage and poor prognosis. Proteomics 2010 Jul; 10, 2644-2660. [PubMed]

7.      Lin C-J, Cheng M-L, Ho H-Y, You T-H, Yu J-S*, Chiu DT-Y* (2010) Impaired dephosphorylation process renders G6PD-deficient cells more susceptible to H2O2-induced apoptosis. Free Radic. Biol. Med. 2010 Aug 1;49(3), 361373. [PubMed]

8.      Chen, J-S, Chen, K-T, Fan C-W, Han C-L, Chen Y-J, Yu J-S, Chang Y-S, Chien C-W, Wu C-P, Hung R-P, Chan E-C* (2010) Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry. FEBS J. 2010 Jul; 277(14), 3028-38. [PubMed]

9.      #Hsieh Y-J, Yu J-S*, Lyu P-C* (2010) Characterization of the photodynamic therapy-elicited responses of A431 cells with intracellular organelle-localized Photofrin. J. Cell. Biochem. 2010 Nov 1, 111(4):821-33. [PubMed]

10.  #Chen Y-T*, Chen C-L, Chen H-W, Chung T, Wu C-C, Chen C-D, Hsu C-W, Chen M-C, Tsui K-H, Chang P-L, Chang Y-S, Yu J-S* (2010) Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology. J. Proteome Res. 2010 Nov 5; 9(11):5803-15. [PubMed]

11.  Mapes J, Chen J-T, Yu J-S, Xue D* (2010) Somatic sex determination in C. elegans is modulated by SUP-26 repression of tra-2 translation. Proc Natl Acad Sci USA 2010 Oct 19;107(42):18022-7. [PubMed]

12.  Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM*, You L* (2011) Cul4A is an oncogene in malignant pleural mesothelioma. J. Cell. Mol. Med. 15(2), 350-358. [PubMed]

13.  Kao H-K, Guo L-F, Cheng M-H, Chen I-H, Liao C-T, Fang K-H, Yu J-S, Chang K-P* (2011) Predicting postoperative morbidity and mortality by model for endstage live disease score for patients with head and neck cancer and liver cirrhosis. Head & Neck 2011 Apr; 33(4):529-34. [PubMed]

14.  Chang K-P, Chang Y-T, Wu C-C, Liu Y-L, Chen M-C, Tsang N-M, Hsu C-L, Chang Y-S, Yu J-S* (2011) Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. Head & Neck 2011 Jun;33(6):886-97. [PubMed]

15.  Liu H-P, Wu C-C, Kao H-Y, Huang Y-C, Liang Y, Chen C-C, Yu J-S, Chang Y-S* (2011) Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration. Mol. Cell. Proteomics 2011 Mar;10(3):M900641MCP200. [PubMed]

16.  Kuo YB, Fan CW, Chan CC, Hung RP, Hung YS, Chen KT, Chang CA, Yu JS, Chang YS, Chan EC* (2011) Identification of phospholipid scramblase 1 as a biomarker and it's prognostic value for colorectal cancer. Mol. Med. 2011 Jan-Feb; 17(1-2):41-47. [PubMed]

17.  Wang C-I, Wang C-L, Wang C-W, Chen C-D, Wu C-C, Tsai Y-H, Chang Y-S, Yu J-S, Yu C-J* (2011) Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of cancer cell secretome and tissue transcriptome. Int. J. Cancer 2011 May; 128(10):2364-72. [PudMed]

18.  Chen J-S, Chou Y-P, Chen K-T, Hung R-P, Yu J-S, Chang Y-S, Chan E-C* (2011) Detection of annexin A autoantibodies in sera from colorectal cancer patients. J. Clin. Gastroenterol. 2011 Feb; 45(2):125-32. [PudMed]

19.  Chang K-P, Kao H-K; Yen T-C, Chang Y-L, Liang Y, Liu S-C, Lee L-Y, Chang Y-L, Kang C-J, Chen I-H, Liao C-T*, Yu J-S* (2011) Overexpression of macrophage inflammatory protein-3a in oral cavity squamous cell carcinoma associated with tumor metastasis. Oral Oncol. 2011 Feb; 47, 108–113. [PubMed]

20.  Hsueh C, Lin J-D*, Wu I-C, Chao T-C, Yu J-S, Liou M-J, Yeh C-J (2011) Angiogenesis in papillary thyroid carcinoma: Expression of vascular endothelial growth factor, angiopoietin-1 angiogoitin-2 and Tie-2 correlated with tumor progression and prognosis. J. Sur. Oncol. 2011 Apr; 103(5):395-9. [PubMed]

21.  Han C-L, Chen J-S, Chan E-C, Wu C-P, Yu K-H, Chen K-T, Tsou C-C, Tsai C-F, Chien C-W, Kuo Y-B, Lin P-Y, Yu J-S, Hsueh C, Chen M-C, Chan C-C, Chang Y-S, Chen Y-J* (2011) An informatics-assisted label-free approach for personalized tissue membrane proteomics: Case study on colorectal cancer. Mol. Cell. Proteomics 2011 Apr;10(4):M110.003087. [PubMed]

22.  Fan CW, Chan CC, Chen KT, Twu J, Huang YS, Han CL, Chen YJ, Yu JS, Chang YS, Kuo YB, Chan EC* (2011) Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer. Clin. Chim. Acta. 2011 May 12;412(11-12):887-93. [PubMed]

23.  Chang K-P, Chang Y-T , Liao C-T, Yen T-C, Chen I-H, Chang Y-L, Liu Y-L, Chang Y-S, Yu J-S*, Wu C-C* (2011) Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling. Clin. Chim. Acta. 2011 May 12;412(11-12):980-7. [PubMed]

24.  Peng P-H, Wu C-C*, Liu S-C, Chang K-P, Chen C-D, Chang Y-T, Hsu C-W, Chang Y-S, Yu J-S* (2011) Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J. Proteomics 2011 May 1;74(5):744-57. [PubMed]

25.      #Chang Y-T, Wu C-C*, Shyr Y-M, Chen T-C, Hwang T-L, Yeh T-S, Chang K-P, Liu H-P, Liu-Y-L, Tsai, M-H, Chang Y-S, Yu J-S* (2011) Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection. PLoS One 6(5), e20029. [PubMed]

26.     Yu C-J, Chang K-P, Chang Y-J, Hsu C-W, Liang Y, Yu J-S, Chi L-M, Chang Y-S, Wu C-C* (2011) Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J. Proteome Res. 2011 Aug 5;10(8):3778-88. [PubMed]

27.     Martel J, Young D, Young A, Wu C-Y, Chen C-D, Yu J-S, Young JD* (2011) Comprehensive proteomic analysis of mineral nanoparticles derived from human body fluids and analyzed by liquid chromatography-tandem mass spectrometry. Anal. Biochem. 2011 Nov 1;418(1):111-25. [PubMed]

28.     Yu C-J*, Wang C-L, Wang C-I, Chen C-D, Dan Y-M, Wu C-C, Wu Y-C, Lee I-N, Tsai Y-H, Chang Y-S, Yu J-S (2011) Comprehensive proteome analysis of malignant pleural effusion for lung cancer biomarker discovery by using multidimensional protein identification technology. J. Proteome Res. 10(10):4671-82. [PubMed]

29.     Chang K-P, Yu J-S, Chien K-Y, Lee C-W, Liang Y, Liao C-T, Yen T-C, Lee L-Y, Huang L-L, Liu S-C, Chang Y-S, Chi L-M* (2011) Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J. Proteome Res. 2011 Nov 4;10(11):4935-47. [PubMed]

30.      #Tsai M-H, Wu C-C, Peng P-H , Liang Y, Shiao Y-C, Chien K-Y, Chen J-T, Lin S-J, Tang R-P, Hsieh L-L*, Yu J-S* (2012) Identification of secretory gelsolin as a plasma biomarker associated with distant organ metastasis of colorectal cancer. J. Mol. Med. (Berl) 90(2), 187-200. [PubMed]

31.      #Chen Y-T, Chen H-W, Domanski D, Smith DS, Liang K-H, Wu C-C, Chen C-L, Chung T, Chen M-C, Chang Y-S, Borchers CH*, Yu J-S* (2012) Multiplexed quantification of 63 proteins by multiple reaction monitoring-based mass spectrometry in human urine for discovery of potential bladder cancer biomarkers. J. Proteomics 75(12):3529-45. [PubMed]

32.     Pan T-L*, Wang P-W, Huang C-C, Yeh C-T, Hu T-H, Yu J-S (2012) Network analysis and proteomic identification of vimentin as a key regulator associated with the invasiveness and metastasis of human hepatocellular carcinoma cells. J. Proteomics 75(15):4676-92. [PubMed]

33.     Wang I-S, Lu T-F, Lue C-E, Huang C-H, Yang P, Lin Y-T, Pijanswska DG, Yang C-M, Wang J-C, Yu J-S, Chang Y-S, Lai C-S* (2012). Immobilization of enzyme and antibody on ALD-HfO2 EIS structure by NH3 plasma treatment. Nanoscale Res. Lett. 7(1):179. 2012 Mar 8 [PubMed]

34.      #Hsieh Y-J, Chien K-Y, Lin S-Y, Sabu S, Hsu R-M, Chi L-M, Lyu P-C, Yu J-S*. (2012) Photofrin binds to procaspase-3 and mediates photodynamic treatment–triggered methionine oxidation and inactivation of procaspase-3. Cell Death Dis. 3: e347; [PubMed]

35.     Wang C-I, Chien K-Y, Wang C-L, Liu H-P, Cheng C-C, Chang Y-S, Yu J-S, Yu C-J* (2012) Quantitative proteomics reveals regulation of KPNA2 and its potential novel cargo proteins in non-small cell lung cancer. Mol. Cell. Proteomics 2012 Nov; 11(11):1105-22. [PubMed]

36.     Chen C-L, Lai Y-F, Tang P, Chien K-Y, Yu J-S, Tsai C-H, Chen H-W, Wu C-C, Chung T, Hsu C-W, Chen C-D, Chang Y-S, Chang P-L, Chen Y-T* (2012) Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients. J. Proteome Res. 11(12):5611-29. [PubMed]

37.     Hsueh C*, Lin J-D, Chang Y-S, Hsueh S, Chao T-C, Yu J-S, Jung S-M, Tseng N-M, Sun J-H, Kuo S-Y, Ueng H-S. (2013) Prognostic significance of expression of pituitary tumor-transforming gene-binding factor (PBF) in papillary thyroid carcinoma. Clin. Endocrinol. (Oxf) 2013 Feb;78(2):303-9.  [PubMed]

38.     Chang Y-F#, Yu J-S#, Chang Y-T, Su L-C, Li Y-C, Wu C-C, Chang Y-S, Lai C-S, Chou C* (2013). The utility of a high-throughput scanning biosensor in the detection of the pancreatic cancer marker ULBP2. Biosens. Bioelectron. 2013 Mar 15; 41, 232-237. [PubMed] #Equal contributions to this research

39.     Chen L-C, Liu M-Y, Hsiao Y-C, Choong W-K, Wu H-Y, Hsu W-L, Liao P-C*, Sung T-Y*, Tsai S-F*, Yu J-S*, Chen Y-J* (2013) Decoding the disease-associated proteins encoded in the human Chromosome 4. J Proteome Res. 2013 Jan 4;12(1):33-44. [PubMed]

40.     Hsuuw Y-D, Chan W-H*, Yu J-S (2013) Ochratoxin A inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway. Int. J. Mol. Sci. 2013 Jan 7;14(1):935-53. [PudMed]

41.     Dong Y-M, Chien K-Y, Chen J-T, Wang TCV, Lin S-J, Yu J-S* (2013) Site-specific separation and detection of phosphopeptide isomers with pH-mediated stacking capillary zone electrophoresis-coupled electrospray ionization-tandem mass spectrometry. J. Sep. Sci. 36(9-10):1582-9. [PubMed]

42.     Lin Y-H*, Chen Y-J, Lai C-S*, Chen Y-T, Chen C-L, Yu J-S, and Chang Y-S (2013) A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based ELISA. Biomicrofluidics 2013 Mar 7; 7(2):24103; [PubMed]

43.     Chen C-L, Lin T-S, Tsai C-H, Wu C-C, Chung T, Chien K-Y, Wu M, Chang Y-S, Yu J-S*, and Chen Y-T* (2013) Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics. J. Proteomics 2013 Jun 24; 85:28-43. [PubMed]

44.     Wang RY*, Kuo R-L, Ma W-C, Huang H-I, Yu J-S, Yen S-M, and Huang C-R, Shih S-R (2013) Heat shock protein-90-beta facilitates enterovirus 71 viral particles assembly. Virology 2013 Sep 1;443(2):236-47. [PubMed]

45.     Chang K-P, Wang C-L, Kao H-K, Liang Y, Liu S-C, Huang L-L, Hseuh C, Hsieh Y-J, Chien K-Y, Chang Y-S, Yu J-S, Chi L-M*. (2013) Overexpression of caldesmon is associated with nodal metastasis and poorer prognosis in oral cavity squamous cell carcinomas. Cancer 119, 4003-11. [PubMed]

46.     Chen J-T, Ho C-W, Chi L-M, Chien K-Y, Hsieh Y-J, Lin S-J, Yu J-S*. (2013) Identification of the lamins A/C phosphoepitope recognized by P-STM antibody in mitotic HeLa S3 cells. BMC Biochem. 2013 Jul 19;14(1):18. [PubMed]

47.      #Lin S-J, Chang K-P, Hsu C-W, Chi L-M, Chien K-Y, Liang Y, Tsai M-H, Lin Y-T, Yu J-S*. (2013) Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. J. Proteomics 2013 Dec 6; 94, 186-201. [PubMed]

48.     Tseng S-P, Teng S-H, Lee P-S, Wang C-F, Yu J-S, Lu P-L*. (2013) Rapid identification of M. abscessus and M. massiliense by MALDI-TOF mass spectrometry with a comparison to sequencing methods and antimicrobial susceptibility patterns. Future Microbiol. 2013 Nov; 8:1381-9. doi: 10.2217/fmb.13.115. [PubMed]

49.     Wang H-J, Hsieh Y-J, Cheng W-C, Lin C-P, Lin Y, Yang S-F, Chen C-C, Izumiya Y, Yu J-S, Kung H-J*, Wang W-C*. (2014) JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. Proc Natl Acad Sci USA 2014 Jan 7; 111(1):279-84. 2013 [PubMed]

50.     Hsu C-W, Yu J-S, Peng P-H, Liu S-C, Chang Y-S, Chang K-P*, and Wu C-C* (2014) Secretomic profiling of primary cells reveals THBS2 as a salivary biomarker of oral cavity squamous cell carcinoma. J. Proteome Res. 2014 Nov 7;13(11):4796-807. [PubMed]

51.      #Chen C-D, Wang C-L, Yu C-J, Chien K-Y, Chen Y-T, Chen M-C, Chang Y-S, Wu C-C*, and Yu J-S* (2014) Targeted proteomic pipeline reveals diagnostic biomarkers for malignant pleural effusion of lung cancer. J. Proteome Res. 2014 Jun 6; 13(6):2818-29. [PubMed]

52.     Fang K-H, Kao H-K, Chi L-M, Liang Y, Liu S-C, Hseuh C, Liao C-T, Yen T-C, Yu J-S, Chang K-P*. (2014) Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. Laryngoscope 2014 Sep;124(9):E354-60. [PubMed]

53.     Wu C-C*#, Chang Y-T#, Chang K-P, Liu Y-L, Liu H-P, Lee I-L, Yu J-S, and Chiang W-F*. (2014) Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2014 Aug;23(8):1569-78. [PubMed]

54.     Juo C-G*, Chen C-L, Fu S-H, Lin S-T, Chen Y-T, Chang Y-S, and Yu J-S. (2014) Mass accuracy improvement of reversed-phase liquid chromatography/electrospray ionization mass spectrometry based urinary metabolomic analysis by post-run calibration using sodium formate cluster ions. Rapid Commun Mass Spectrom 28(16), 1813–1820. [PubMed]

55.      #Hsu R-M, Hiesh Y-J, Yang T-H, Chiang Y-C, Kan C-Y, Lin Y-T, Chen J-T, and Yu J-S*. (2014) Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor β (βPIX) to myosin 18A (MYO18A) is required for epithelial cell migration. BBA-Mol Cell Res. 1843 (11), 2513-2527. [PubMed]

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