Your browser does not support JavaScript!
:::
鄭邑荃

鄭邑荃

職稱 副教授

研究室名稱:神經發育、退化、與腫瘤

最高學歷Ph.D.

學校/國家:長庚大學

分機號碼3396

電子郵件帳號yccheng@mail.cgu.edu.tw

個人網頁網址:

研究室現有:博士後研究員1

博士班研究生2

碩士班研究生4

專任研究助理1

大學部專題生5

Update2016/8/3

研究方向研究室特色

 

神經系統發育、神經退化疾病、神經腫瘤形成之分子調控機制

 

神經系統乃由多樣不同功能之神經細胞所構成,這些細胞皆源自於神經幹細胞,經由增生、分化、移行、及死亡等過程而發育成熟,組成具完整生理功能的神經系統。這些發育過程皆需要精準的分子調控,而異常的分子調控可影響神經細胞成長,導致疾病或腫瘤形成。因此,我們研究在胚胎時期神經系統發育之分子調控機制,並研究這些調控機制的異常如何造成神經退化疾病以及神經腫瘤的形成,以開發新的治療方法。

 

關於神經退化疾病方面,我們著重於神經發育缺損如何造成失智症、漸凍人、及癲癇,及其治療方法。

 

關於神經腫瘤方面,我們研究神經膠質瘤(glioma)以及髓母細胞瘤(medulloblastoma)的形成與治療。

 

我們以斑馬魚胚胎、人類神經幹細胞、與神經腫瘤細胞為研究工具。重點為研究NotchRGS訊息傳遞及其調控因子於神經發育、神經退化疾病、及神經腫瘤中之功能。並將利用研究成果開發新治療藥物。

 

 

最近五年所發表論文:

 

1.   Chiang MC, Nicol CJ, Cheng YC, Lin KH, Yen CH, Lin CH (2016, Apr). Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction and oxidative stress. Neurobiology of aging, 40:181-90. (SCI, NEUROSCIENCES 42/252).

2.   Hung FC, Shih HY, Cheng YC, Chao CC. (2015, Dec). Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish. Stem Cells and Development, 015 Dec 15;24(24):2943-51. (SCI).

3.   Yi-Chuan Cheng*, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Ching-Yu Lin, Sheng-Jia Lin, Ching-Chi Chiu, Ching-Wen Huang and Yun-Jin Jiang (2015, Dec). Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Development, (2015) 10:28 (published online ahead of print). (SCI).

4.   Chiang MC, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chen SJ, Huang RN. (2015, Nov). Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Experimental Cell Research, 2015 Nov 1;338(2):183-93. (SCI, 86/211, ONCOLOGY).

5.   Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC (2015, May). The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPKdependent. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1852(5), 720-31. (SCI, Biochimstry and Molecular Biology (54/291)).

6.   Cheng YC*, Chiang MC, Shih HY, Ma TL, Yeh TH, Huang YC, Lin CY, Lin SJ. (2015, Jan). The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Developmental Biology, 397(1), 116-28. (SCI, Developmental Biology (9/41)). CMRPD170511-170513

7.   Huang YC, Shih HY, Lin SJ, Chiu CC, Ma TL, Yeh TH, Cheng YC*. (2015, May). The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Developmental Neurobiology, 75(5):452-62. (SCI, Developmental Biology (7/41)).

8.   Chiang MC, Cheng YC, Chen HM, Liang YJ, Yen CH. (2014, Jan). Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion, 14(1):7-17. (SCI, 42/161, Genetics & Heredity).

9.   Chen SY, Shih HY, Lin SJ, Hsiao CD, Li ZC, Cheng YC*. (2013, Dec). Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science, 126:5626-34. (SCI, 38/185, Cell Biology).

10. Yeh CW, Kao SH, Cheng YC, Hsu LS. (2013, Sep). Knockdown of cyclin dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression. Journal of Biological Chemistry, 288(39):27927-39. (SCI, 62/290, Biochemistry & Molecular Biology).

11. Hsieh FY, Ma TL, Shih HY, Lin SJ, Huang CW, Wang HY, Cheng YC* (2013, Mar). Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Developmental Biology, 375(1), 1-12. (SCI, 7/40, Developmental Biology).

12. YL Lin, YJ Tsai, YF Liu, YC Cheng, CM Hung, YJ Lee, HC Pan, C Li (2013, Mar). The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1. PLoS ONE, 8(3), e55221. (SCI, 12/85, Biology).

13. Cheng YC*, Hsieh FY, Chiang MC, Scotting PJ, Shih HY, Lin SJ, Wu HL, Lee HT (2013, Jan). Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with Notch signaling. PLoS ONE, 8(1):e54262. (SCI, 12/85, Biology).

14. Chiang MC, Cheng YC, Lin KH, Yen CH (2013, Jan). PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha. Neuroscience, 229, 118–129. (SCI, 94/224, Neurosciences).

15. Hung FC, Cheng YC, Sun NK, Chao CC (2013, Jan). Identification and functional characterization of zebrafish Gas7 gene in early development. Journal of Neuroscience Research, 91(1), 51-61. (SCI, 123/244, Neurosciences).

16. Cheng YC*, Scotting PJ, Hsu LS, Lin SJ, Shih HY, Hsieh FY, Wu HL, Tsao CL, Shen CJ. (2012, Oct). Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling. Cellular and Molecular Life Sciences, 70(5), 935-950. (SCI, 33/181, Cell Biology).

17. Hsu SY, Cheng YC, Shih HY, Ouyang P (2012, Jul). Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages. Histochemistry and Cell Biology, 138(1), p127-40. (SCI, 2/10, Microscopy).

18. Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH (2012, Jun). Betaadrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system. Journal of Neuroscience Methods, 207(2), p130-6. (SCI, 175/244, Neurosciences).

19. Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC* (2011, Sep). Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD. Journal of the American Society of Nephrology, 22(9), 1696-1706. (SCI, 1/73, Urology and Nephrology).

20. Chung PC, Lin WS, Scotting PJ, Hsieh FY, Wu HL, Cheng YC* (2011, Apr). Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis. PLoS One, 6(4), e19394. (SCI, 12/85, Biology).


 

         

 

 

瀏覽數  
  • 友善列印
  • 新增到收藏夾
  • 分享
將此文章推薦給親友
請輸入此驗證碼
Voice Play
更換驗證碼