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Department of Biochemistry and Molecular Biology

:::

Dr. Jim-Tong Horng

Jim-Tong Horng

Appointment : Professor and Head

LabCell Biology Laboratory

Education : Ph.D.

University/NationCambridge University/UK

Tel: 03 2118800 ext 5156

E-mail : jimtong@mail.cgu.edu.tw

Research website :  https://horng0866.wixsite.com/jimtong

Research interests:

Molecular analysis of enterovirus 71-host interaction: Enterovirus 71 (EV71) is an enterovirus of the family Picornaviridae that possesses a positive-stranded RNA genome. Positive-stranded RNA virus infection induces the rearrangement of intracellular membranes into characteristic vesicles which assemble into an RNA replication complex where the viral RNA replication takes place. We have been keen in the understanding the EV71 replication process, in which we have identified host proteins, miRNA, and ER stress signaling pathways required for replication complex-associated membrane formation.

Drug discovery against EV71 and influenza viruses: Recurring of enterovirus 71 and influenza virus imposes substantial financial and social burdens each year worldwide. The current lack of approved therapeutic agents for EV71 and emerging drug-resistant influenza viruses motivate us to develop new antiviral compounds. We aim to identify and study the antiviral mechanisms of the small synthetic compound and natural products, and to test their in vivo activities in animal models.

 

 

Publications: (2012-2016)

1           Ho, J. Y., Chern, J. H., Hsieh, C. F., Liu, S. T., Liu, C. J., Wang, Y. S., Kuo, T. W., Hsu, S. J., Yeh, T. K., Shih, S. R., Hsieh, P. W., and Horng*, J. T. (2016) In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. Journal of Antimicrobial Chemotherapy (accepted), IF=5.313, PHARMACOLOGY & PHARMACY: 17/255=6.67%

2           Jheng, J. R., Wang, S. C., Jheng, C. R., and Horng*, J. T. (2015) Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication. Emerging Microbes & Infections (In press), IF=2.258, Microbiology: 72/119=60.50%

3           Tang, W. F., Huang, R. T., Chien, K. Y., Huang, J. Y., Lau, K. S., Jheng, J. R., Chiu, C. H., Wu, T. Y., Chen, C. Y., and Horng*, J. T. (2016) Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. Journal of virology 90, 1424-1438, IF=4.439, Microbiology: 7/33=21.21%

4           Wu, M. J., Ke, P. Y., and Horng*, J. T. (2014) RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication. Biochemical and biophysical research communications 454, 19-24, IF=2.297, BIOPHYSICS: 41/73=56.16%

5           Jheng, J. R., Ho, J. Y., and Horng*, J. T. (2014) ER stress, autophagy, and RNA viruses. Frontiers in microbiology 5, 388, IF=3.989, Microbiology: 27/119=22.69%

6           Wu, M. J., Ke, P. Y., Hsu, J. T., Yeh, C. T., and Horng*, J. T. (2014) Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction. Cellular microbiology 16, 1603-1618, IF=4.915, Microbiology: 18/119=15.13%

7           Ho, J. Y., Chang, H. W., Lin, C. F., Liu, C. J., Hsieh, C. F., and Horng*, J. T. (2014) Characterization of the anti-influenza activity of the Chinese herbal plant Paeonia lactiflora. Viruses 6, 1861-1875, IF=3.353, VIROLOGY: 12/33=36.36%

8           Hsieh, C. F., Yen, H. R., Liu, C. H., Lin, S., and Horng*, J. T. (2012) Ching-fang-pai-tu-san inhibits the release of influenza virus. Journal of ethnopharmacology 144, 533-544

9            Yeh, J. Y., Coumar, M. S., Shiao, H. Y., Lin, T. J., Lee, Y. C., Hung, H. C., Ko, S., Kuo, F. M., Fang, M. Y., Huang, Y. L., Hsu, J. T., Yeh, T. K., Shih, S. R., Chao, Y. S., Horng*, J. T., and Hsieh*, H. P. (2012) Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization. ChemMedChem 7, 1546-1550

10       Jheng, J. R., Lin, C. Y., Horng*, J. T., and Lau, K. S. (2012) Inhibition of enterovirus 71 entry by transcription factor XBP1. Biochemical and biophysical research communications 420, 882-887

11       Hsieh, C. F., Lo, C. W., Liu, C. H., Lin, S., Yen, H. R., Lin, T. Y., and Horng*, J. T. (2012) Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. Journal of ethnopharmacology 143, 57-67

12       Chang, C. W., Leu, Y. L., and Horng*, J. T. (2012) Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. Viruses 4, 539-556

13       Hsu, J. T., Yeh, J. Y., Lin, T. J., Li, M. L., Wu, M. S., Hsieh, C. F., Chou, Y. C., Tang, W. F., Lau, K. S., Hung, H. C., Fang, M. Y., Ko, S., Hsieh, H. P., and Horng*, J. T. (2012) Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus. Antimicrob Agents Chemother 56, 647-657

14       Wu, M. S., Yen, H. R., Chang, C. W., Peng, T. Y., Hsieh, C. F., Chen, C. J., Lin, T. Y., and Horng*, J. T. (2011) Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of ethnopharmacology 134, 614-623

 

 

 

 

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