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Department of Biochemistry and Molecular Biology

:::

Dr. Hsuan Liu

Hsuan Liu

Appointment : Assistant Professor

Labfunctional and cancer genomic lab

Education : Ph.D.

University/NationInstitute of Molecular Medicine, National Taiwan University, Taiwan

Tel:+886-3-211-8800 ext.3526

E-mail : liu-hsuan@mail.cgu.edu.tw

Research website :

Research interests:

At the molecular level, the hallmark of tumor malignancy comprises dysregulation of several cellular signaling networks attributable to genetic and epigenetic changes. Recent next-generation or deep sequencing (NGS) studies have provided a more global view of the genetic and epigenetic origins of different cancer. My research is focused mainly on establishing and applying various NGS-based technologies to systematically profile nucleotide variants (at the genome or transcriptome level) in cancer samples, and explore the disease relevance of these mutational “bio-signatures”. Major research aims and platforms include, but not limited to:

1.    Targeted genome re-sequencing analysis of oral squamous cell carcinoma

2.    Targeted genome re-sequencing analysis of colorectal cancer

3.    Targeted genome re-sequencing analysis of nasopharyngeal cancer

4.    Transcriptomic sequencing (RNA-seq) analysis of host response to EV71 infection

5.    RNA-seq and small RNA-seq of tissues derived from oral cancer animal model

6.    Small RNA-seq analysis of urine samples from acute kidney injury and chronic kidney disease

7.    RNA-IP-seq analysis of RNA-binding protein-associated RNAs

We complement these functional genomic experiments with cell-based and animal studies to further delineate molecular mechanisms underlying the pathological roles of these variants. Our ultimate goal is to uncover sequence variants and/or gene regulatory mechanisms that are novel diagnostic or therapeutic targets. Furthermore, we aim to establish close integration of proteomic and genomic data generated by the Molecular Medicine Research Center for translational medicine application.



Publications:

 

1.      WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway.
Hsieh CL, Lin CL, Liu H, Chang YJ, Shih CJ, Zhong CZ, Lee SC, Tan BC. (co-author)

Nucleic Acids Res. 2011 May; 39(10):4048-62.

BIOCHEMISTRY & MOLECULAR BIOLOGY 20/290

 

2.      Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.

Yang CC*, Liu H*, Chen SL, Wang TH, Hsieh CL, Huang Y, Chen SJ, Chen HC, Yung BYM, Tan BC. (*first author)

EMBO J. 2012 Apr; 31(7): 1739-1751.

 BIOCHEMISTRY & MOLECULAR BIOLOGY11/29

 

3.      Epigenetic silencing of ribosomal RNA genes by Mybbp1a.

Tan BC, Yang CC, Hsieh CL, Chou YH, Zhong CZ, Yung BYM*, Liu H*.  (corresponding author)

J Biomed Sci. 2012 Jun; 19:57.

MEDICINE, RESEARCH & EXPERIMENTAL50/123

 

4.      A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells.

   Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. (Co-author)

   Hepatology. 2013 May; 57(5):1893-905.

GASTROENTEROLOGY & HEPATOLOGY 5/76

 

5.      CPAP: Cancer Panel Analysis Pipeline.

Huang PJ, Yeh YM, Gan RC, Lee CC, Chen TW, Lee CY, Liu H, Chen SJ, Tang P. (co-author)

Hum Mutat. 2013 Oct; 34(10):1340-6. 

GENETICS & HEREDITY 25/167

 

6.      A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1.

Chen HW, Yang CC, Hsieh CL, Liu H, Lee SC, Tan BC. (Co-author)

Biochim Biophys Acta. 2013 Nov 1. doi:pii: S1874-9399(13)00155-7.10.1016/j.bbagrm.2013.10.006.  BIOCHEMISTRY & MOLECULAR BIOLOGY 34/290

 

7.      ADAR1 deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions.

Hsieh CL, Liu H, Huang Y, Kang L, Chen HW, Chen YT, Wee YR, Chen SJ, and Tan BC. (Co-author)

Cell Death Differ.2014 May; 21(5):707-719.

BIOCHEMISTRY & MOLECULAR BIOLOGY 24/290

 

8.      Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.

Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih SR. (Co-author)

PLoS Pathog. 2014 Jun; 10(6):e1004199.

MICROBIOLOGY 10/119

 

9.      Functional impact of RNA editing and ADARs on regulation of gene expression: perspectives from deep sequencing studies.

Liu H, Ma CP, Chen YT, Schuyler SC, Chang KP, Tan BC. (First author)

   Cell & Bioscience. 2014 Aug 19; 4:44.

   BIOCHEMISTRY & MOLECULAR BIOLOGY 89/290

 

10.  Vanno: A Visualization-aided Variant Annotation Tool.

Huang PJ, Lee CC, Tan BC, Yeh YM, Huang KY, Gan RC, Chen TW, Lee CY, Yang ST, Liao CS, Liu H*, Tang P*. (*corresponding author)

Hum Mutat. 2015 Feb;36(2):167-74.

GENETICS & HEREDITY 25/167

 

11.  CMPD: cancer mutant proteome database.

Huang PJ, Lee CC, Tan BC, Yeh YM, Chu LJ, Chen TW, Chang KP, Lee CY, Gan RC, Liu H*, Tang P*. (*corresponding author)

Nucleic Acids Res. 2015 Jan;43(Database issue):D849-55.

BIOCHEMISTRY & MOLECULAR BIOLOGY 20/290

 

12.  Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.

Chen WY, Shih HT, Liu KY, Shih ZS, Chen LK, Tsai TH, Chen MJ, Liu H, Tan BC, Chen CY, Lee HH, Loppin B, Aït-Ahmed O, Wu JT. (Co-author)

EMBO Rep. 2015 Apr;16(4):528-38.

BIOCHEMISTRY & MOLECULAR BIOLOGY 22/290

 

13.  Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature.

Chen SJ*, Liu H*, Liao CT, Huang PJ, Huang Y, Hsu A, Tang P, Chang YS, Chen HC, Yen TC. (*first author)

Oncotarget. 2015 Jul 20;6(20):18066-80

ONCOLOGY 21/211

 

14.  Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates.

Yang XZ, Chen JY, Liu CJ, Peng J, Wee YR, Han X, Wang C, Zhong X, Shen QS, Liu H, Cao H, Chen X, Tan BC, Li CY. (Co-author)

Mol Biol Evol. 2015 Dec;32(12):3143-57

GENETICS & HEREDITY 10/167

 

15.  ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance.

Chung IH*, Liu H*, Lin YH, Chi HC, Huang YH, Yang CC, Yeh CT, Tan BC, Lin KH. ( *first author)

Oncotarget. 2016 Mar 8. doi: 10.18632/oncotarget.7988. [Epub ahead of print]

ONCOLOGY 21/21

 

 

 

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