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Department of Biochemistry and Molecular Biology

:::

Dr. Albert M.-D. Wu

Albert M.-D. Wu

Appointment : Professor 

Lab :  Glyco-immunochemistry Lab.

Education : Ph.D.

University/NationBasic Medical Science-Major: Biochemistry, New York Medical College 

Tel+886-3-211-8800 ext.5175

E-mailamwu@mail.cgu.edu.tw

Research Description

    Knowledge of the structures and binding properties of antigenic determinants and active sites (epitopes) of complex carbohydrates will contribute to a better understanding of the functional roles of these carbohydrates at the molecular level, and will provide us with valuable information about the following aspects: (a) understanding life process, mechanism of infections, inflammation, genetic disorders and cancer; (b) producing new reagents to detect cancer; (c) for developing vaccines and drugs to prevent infection, and (d) for improving serodiagnosis.

 

   Publications : 

(1)   Wu : 複雜性碳水化合物在生物醫學上的重要性. Chemistry (The Chinese Chem. Soc., Taiwan), Vol.52, No.4, 462-476, Dec., 1994;

(2)   Wu (ed): “The Molecular Immunology of Complex Carbohydrates.” Adv. Exp. Med. & Biol. 228, (868 pages). Plenum Press, New York and London, 1988. (長庚醫院圖書館有存放);

(3) Defining the Carbohydrate Specificities of Abrus precatorius agglutinin as T (Galb1®3GalNAc) > I/II (Gal b1®3/4GlcNAc). J. Biol. Chem., 267: 19130-19139, 1992;

(4) The Biotin/Avidin-Mediated Microtiter Plate Lectin Assay with the Use of Chemically Modified Glycoprotein Ligand. Analytical Biochem., 221: 266-272, 1994;

(5) A Sheep Hydatid Cyst Glycoprotein as Receptors for three Toxic Lectins, as well as Abrus Precatorius and Ricinus Communis Agglutinins. Biochim. Biophys. Acta., 1243: 124-128, 1995.

(6) 淺談Gal GalNAc有特異性的應用凝集素(Applied lectins)對醣類結合性質的表達和分類. 生命科學簡訊, 第十二卷,第一期, P.6, 1998.

(7) Studies on the binding of wheat germ agglutinin (Triticum vulgaris) to O-glycans. FEBS Letter, 440:315-319, 1998. (10) Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A4 (GSI-A4). Glycobiology, in press, 1999.

 

Copyright © 2009 Department of Biochemistry and Molecular Biology Chang-Gung University

 

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