吳嘉霖

吳嘉霖

職稱：教授 兼 醫學系醫預科主任

研究室名稱：學習與記憶研究室

最高學歷：博士

學校/國家：清華大學/台灣

分機號碼：5159

電子郵件帳號：clwu@mail.cgu.edu.tw

個人網頁網址：https://clwu88.wixsite.com/chialinwu-lab

研究室現有： 博士後研究員 1 人

博士班研究生  1 人

碩士班研究生 3 人

專任研究助理 3 人

大學部專題生 6 人

Update：2022/08/08

研究方向及研究室特色：

人類如何將學習的經驗轉為記憶儲存一直都是科學界最想解開的謎題。人類擁有高度學習與記憶的能力，使人類祖先能在惡劣的自然環境中生存，進而成為優勢物種。俗話說:”一朝被蛇咬，十年怕草繩”就是一個例子。先前被毒蛇咬過而大難不死的人，將毒蛇的樣子與危險訊號兩種訊息關聯在一起並轉變為記憶儲存，下次再看到相似外型的物體，先前儲存的記憶便會被喚起，出現恐懼的感覺進而產生警戒。而這些記憶的形成是由大腦上千億顆神經元共同運作的結果，但確切機制目前仍然未知。我們研究室利用果蠅作為模式生物了解大腦在學習與記憶過程中產生哪些生理變化。果蠅大腦僅有約十三萬顆神經細胞，相較於人腦由將近千億顆神經細胞組成相對簡單。我們利用大腦組織免疫染色搭配共軛焦顯微鏡技術觀察果蠅大腦內神經分子的變化情形，進而了解記憶過程中大腦的分子變化情形。搭配活體大腦鈣離子影像系統研究果蠅大腦在學習前與學習後的神經反應變化情形。另外利用動物行為學分析觀察特定基因突變或特定神經細胞的神經活性改變是否影響果蠅學習與記憶能力。這些實驗結果都將使我們更加了解記憶形成的大腦神經機制。

最近五年所發表論文：

  1. Chen SL, Liu BT, Lee WP, Liao SB, Deng YB, Wu CL, Ho SM, Shen BX, Khoo GH, Shiu WC, Chang CH, Shih HW, Wen JK, Lan TH, Lin CC, Tsai YC, Tzeng HF, Fu TF. (2022). WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour. Nature Communications, 13:2518/ doi.org/10.1038/s41467-022-30165-2
  2. Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai TH, Wu CL. (2022). Drosophila Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases. Biomedicines, Mar; 10, 596. doi.org/10.3390/biomedicines10030596.
  3. Lee WP, Chiang MH, Chang LY, Shyu WH, Chiu TH, Fu TF, Wu T, Wu CL. (2021). Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory in Drosophila. Frontiers in Cell and Developmental Biology, Nov 11; 9:755574.
  4. Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH, Wu CL, Lin HJ, Chiu CH, Lai CH. (2021). Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence, Dec;12(1):2341-2351.
  5. Cheng KC, Chen YH, Wu CL, Lee WP, Cheung CHA, Chiang HC. (2021).Rac1 and Akt Exhibit Distinct Roles in Mediating Aβ-Induced Memory Damage and Learning Impairment. Molecular Neurobiology, Jul 17. doi: 10.1007/s12035-021-02471-1.
  6. Lee WP, Chiang MH, Chang LY, Lee JY, Tsai YL, Chiu TH, Chiang HC, Fu TF, Wu T, Wu CL*. (2020) Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila. PLOS Genetics, 16(8): e1008963. (*corresponding author).
  7. Lien WY, Chen YT, Li YJ, Wu JK, Huang KL, Lin JR, Lin SC, Hou CC, Wang HD, Wu CL, Huang SY, Chan CC*. (2020). Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. Aging Cell, e13179 doi 10.1111/acel.13179.
  8. Shyu WH, Lee WP, Chiang MH, Chang CC, Fu TF, Chiang HC, Wu T, Wu CL* (2019). Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila. PLOS Genetics, 15(5): e1008153. (*corresponding author).
  9. Sneapati B, Tsao CH, Juan YA, Chiu TH, Wu CL, Waddell S, Lin S*. (2019). A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila. Nature Neuroscience, 22(12): 2029-2039.
  10. Chen YR, Li YH, Hsieh TC, Wang CM, Cheng KC, Wang L, Lin TY, Cheung CHA, Wu CL, Chiang H* (2019). Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity. Aging Cell, 18(4) e12989.
  11. Chi KC, Tsai WC, Wu CL, Lin TY, Hueng DY (2019). An adult Drosophila glioma model for studying pathometabolic pathways of gliomagenesis. Molecular Neurobiology, 56(6): 4589-4599.
  12. Lien HM, Wu HY, Hung CL, Chen CJ, Wu CL, Chen KW, Huang CL, Chang SJ, Chen CC, Lin HJ, Lai CH* (2019). Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori. Scientific Reports, (9)1: 4205. doi: 10.1038/s41598-019-40735-y.
  13. Wu CL*, Chang CC, Wu JK, Chiang MH, Yang CH, Chiang HC (2018). Mushroom body glycolysis is required for olfactory memory in Drosophila. Neurobiology of Learning and Memory, 150: 13-19 (*corresponding author).
  14. Chen YA, Tzeng D TW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH* (2018). Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers, 11(1): 34. doi 10.3390/cancers11010034.
  15. Chen YA, Shih HW, Lin YC, Hsu HY, Wu TF, Tsai CH, Wu CL, Wu HY, Hsieh JT, Tang CH, Lai CH* (2018). Simvastatin sensitizes radioresistant prostate cancer cells by compromising DNA double-strand break repair. Frontiers in Pharmacology, 9: 600.
  16. Ji XR, Cheng KC, Chen YR, Lin TY, Cheung CHA, Wu CL, Chiang HC* (2018). Dysfunction of different cellular degeneration pathways contributes to specific β-amyloid42-induced pathologies. FASEB Journal, 32(3): 1375-1387. 
  17. Yang CN, Wu MF, Liu CC, Jung WH, Chang YC, Lee WP, Shiao YJ, Wu CL, Liou HH, Lin SK, Chan CC* (2017) Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human Molecular Genetics, 26(20): 3909-3921.
  18. Shyu WH, Chiu TH, Chiang MH, Cheng YC, Tsai YL, Fu TF, Wu T, Wu CL* (2017). Neural circuits for long-term water-reward memory processing in thirsty Drosophila. Nature Communications, 8: 15230; doi: 10.1038/ncomms15230 (*corresponding author).
  19. Chen SL, Chen YH, Wang CC, Yu YW, Tsai YC, Hsu HW, Wu CL, Wang PY, Chen LC, Lan TH*, Fu TF* (2017). Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons. Scientific Reports, 7:44595/doi:10.1038/srep44595.

近五年內獲獎情形及重要會議邀請演講：

獲獎：

  1. 2019長庚大學優良教師—教學獎
  2. 56屆中華民國十大傑出青年—醫學研究類
  3. 2018長庚大學優良教師—研究獎
  4. 2018中央研究院年輕學者研究著作獎—生命科學組
  5. 106年度科技部吳大猷先生紀念獎
  6. 2017長庚大學優良教師—研究獎

邀請演講：

1. Wu CL, Invited speaker. Asia-Pancific Drosophila Neuroscience Conference（APDNC）. January 16-20, 2019, Taipei, Taiwan. Electrical synapses in Kenyon cells are critical for Drosophila olfactory memory.

2. Wu CL, Invited speaker. The Research Center of Developmental Biology and Research Medicine at National Taiwan University (NTUCDBRM). October 30th2018, Taipei, Taiwan. Dissecting neural path-ways for Drosophila water reward long-term memory.

3. Wu CL, Invited speaker. The 13thAcross the Taiwan Strait Symposium on Cell Biology. July 18th-22th2018, Xining, China. Parallel brain circuits regulate long-and short-term memories in fruit fly.

4. Wu CL, Invited speaker. EMBO Workshop on Neural Development. March 2nd-6rd2018, Taipei, Taiwan. Water reward memory in Drosophila.

5. Wu CL, Invited speaker. NPAS Symposium on Drosophila Neurobiology. July 26th2017, Taipei, Tai-wan. Water reward long-term memory in Drosophila.