Dr. Yi-Chuan Cheng


Yi-Chuan Cheng

Yi-Chuan Cheng

Appointment :  Professor

LabNeural Development, Degeneration, and Tumorigenesis

Education : Ph.D.

University/NationChang Gung University

Tel: +886 3 2118800 ext 3396

E-mail : yccheng@mail.cgu.edu.tw

Research website :

Research interests:

The neural progenitors exhibit self-renewing and multipotency and are capable to differentiate into diverse collection of neural cells such as neurons, astrocytes, and oligodendrocytes. The pathways regulating their survival, proliferation, differentiation, and migration are frequently disrupted or altered in many neurodegenerative disorders and brain tumors. Therefore, understanding the gene regulatory and signaling processes in neural development may provide directly knowledge relevant to neural degeneration and brain tumorigenesis and lead to novel therapies and strategies that will advance the treatment of these diseases. We are investigating how aberrant developmental processes contribute to degeneration and tumors with a particular focus on the role of Notch and RGS signaling pathways in regulating neural development, neural degeneration, and brain tumorigenesis, using zebrafish, neural stem cells, and brain tumor cells as models.




1.     Chiang MC, Nicol CJ, Cheng YC, Lin KH, Yen CH, Lin CH (2016, Apr). Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction and oxidative stress. Neurobiology of aging, 40:181-90. (SCI, NEUROSCIENCES 42/252).

2.     Hung FC, Shih HY, Cheng YC, Chao CC. (2015, Dec). Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish. Stem Cells and Development, 015 Dec 15;24(24):2943-51. (SCI).

3.     Yi-Chuan Cheng*, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Ching-Yu Lin, Sheng-Jia Lin, Ching-Chi Chiu, Ching-Wen Huang and Yun-Jin Jiang (2015, Dec). Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Development, (2015) 10:28 (published online ahead of print). (SCI).

4.     Chiang MC, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chen SJ, Huang RN. (2015, Nov). Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Experimental Cell Research, 2015 Nov 1;338(2):183-93. (SCI, 86/211, ONCOLOGY).

5.     Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC (2015, May). The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPKdependent. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1852(5), 720-31. (SCI, Biochimstry and Molecular Biology (54/291)).

6.     Cheng YC*, Chiang MC, Shih HY, Ma TL, Yeh TH, Huang YC, Lin CY, Lin SJ. (2015, Jan). The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Developmental Biology, 397(1), 116-28. (SCI, Developmental Biology (9/41)). CMRPD170511-170513

7.     Huang YC, Shih HY, Lin SJ, Chiu CC, Ma TL, Yeh TH, Cheng YC*. (2015, May). The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Developmental Neurobiology, 75(5):452-62. (SCI, Developmental Biology (7/41)).

8.     Chiang MC, Cheng YC, Chen HM, Liang YJ, Yen CH. (2014, Jan). Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion, 14(1):7-17. (SCI, 42/161, Genetics & Heredity).

9.     Chen SY, Shih HY, Lin SJ, Hsiao CD, Li ZC, Cheng YC*. (2013, Dec). Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science, 126:5626-34. (SCI, 38/185, Cell Biology).

10.   Yeh CW, Kao SH, Cheng YC, Hsu LS. (2013, Sep). Knockdown of cyclin dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression. Journal of Biological Chemistry, 288(39):27927-39. (SCI, 62/290, Biochemistry & Molecular Biology).

11.   Hsieh FY, Ma TL, Shih HY, Lin SJ, Huang CW, Wang HY, Cheng YC* (2013, Mar). Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Developmental Biology, 375(1), 1-12. (SCI, 7/40, Developmental Biology).

12.   YL Lin, YJ Tsai, YF Liu, YC Cheng, CM Hung, YJ Lee, HC Pan, C Li (2013, Mar). The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1. PLoS ONE, 8(3), e55221. (SCI, 12/85, Biology).

13.   Cheng YC*, Hsieh FY, Chiang MC, Scotting PJ, Shih HY, Lin SJ, Wu HL, Lee HT (2013, Jan). Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with Notch signaling. PLoS ONE, 8(1):e54262. (SCI, 12/85, Biology).

14.   Chiang MC, Cheng YC, Lin KH, Yen CH (2013, Jan). PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha. Neuroscience, 229, 118–129. (SCI, 94/224, Neurosciences).

15.   Hung FC, Cheng YC, Sun NK, Chao CC (2013, Jan). Identification and functional characterization of zebrafish Gas7 gene in early development. Journal of Neuroscience Research, 91(1), 51-61. (SCI, 123/244, Neurosciences).

16.   Cheng YC*, Scotting PJ, Hsu LS, Lin SJ, Shih HY, Hsieh FY, Wu HL, Tsao CL, Shen CJ. (2012, Oct). Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling. Cellular and Molecular Life Sciences, 70(5), 935-950. (SCI, 33/181, Cell Biology).

17.   Hsu SY, Cheng YC, Shih HY, Ouyang P (2012, Jul). Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages. Histochemistry and Cell Biology, 138(1), p127-40. (SCI, 2/10, Microscopy).

18.   Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH (2012, Jun). Betaadrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system. Journal of Neuroscience Methods, 207(2), p130-6. (SCI, 175/244, Neurosciences).

19.   Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC* (2011, Sep). Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD. Journal of the American Society of Nephrology, 22(9), 1696-1706. (SCI, 1/73, Urology and Nephrology).

20.   Chung PC, Lin WS, Scotting PJ, Hsieh FY, Wu HL, Cheng YC* (2011, Apr). Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis. PLoS One, 6(4), e19394. (SCI, 12/85, Biology).