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林光輝

林光輝老師

中文姓名：林光輝

職稱：特聘教授

研究室名稱：基因調控

最高學歷：Ph.D.

學校/國家：阿拉巴馬大學/美國

分機號碼：88632118800 ext.5975

電子郵件帳號：khlin@mail.cgu.edu.tw

個人網頁網址：http://lncrna103.wixsite.com/cgu-lkh

研究室現有： 博士後研究員  2 人

博士班研究生  0  人

碩士班研究生 0 人

專任研究助理  1  人

大學部專題生   0  人

Update：2022/12/26

研究方向及研究室特色：  

甲狀腺素在肝臟之異常調控導致肝臟病變產生肝癌之機制。

  1. 甲狀腺素受體可調控下游基因表現，包括miRNAs, long non-coding (Lnc)RNAs影響細胞的生長、分化和發育之機制。利用之工具:
  1. 基因體  microarray; 2.蛋白質體。

  1. 腫瘤標識找尋: 利用基因體和蛋白質體技術系統性分析胃癌、子宮頸癌或皮膚癌中表現異常之基因(含small RNAs, LncRNA)，及biomarkers的找尋。

  1. 甲狀腺素受體調控自噬機制。

E.  LncRNAs在肝癌中之角色及調控。

      

LncRNAs在肝癌中之角色及調控

三、近五年內獲獎情形及重要會議邀請演講

1.科技部傑出研究獎 (2017)

2.長庚大學特聘教授 (2015-迄今)

3.長庚大學優良教師研究獎 (2005、2012、2017、2018、2019、2022)

4.肝病防治基金會最佳論文(2013、2015、2017)

5.第28屆(2018)王民寧獎--基礎醫學-傑出貢獻獎

2015-2022著作目錄 (selected publication,全部是通訊作者, 不包括共同作者之SCI論文)  December 26, 2022 updated

  1. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author) Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression Int. J. Cancer 140(7), 1581-1596. 2017 (SCI; IF: 7.396, 42/242=17.4%, Oncology)
  2. I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh and K-H Lin (corresponding author) The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma Sci. Rep. 7:295 doi: 10.1038/s41598-017-00382-7, 2017 (SCI; IF: 4.38, 17/72=23.6%, multidisciplinary sciences)
  3. Hsiang-Cheng Chi, Shen-Liang Chen, Syuan-Ling Lin, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone protect hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover Oncogene 36(37), 5274-5284, 2017 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)
  4. Tzu-Kang Lin, Chang-Nen Chang, Cheng-Shian Tsai, Yin-Cheng Huang, Yu-Jen Lu, Wei-Jan Chen, Yang-Hsiang Lin, I-Hsiao Chung and K-H Lin (corresponding author) The long non-coding RNA LOC441204 enhances cell growth in human glioma Sci. Rep. 7(1):5603. 2017 (SCI; IF: 4.38, 17/72=23.6%, multidisciplinary sciences)
  5. Hsiang-Cheng Chi , Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin  Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells Int. J. Mol. Sci. 18(9). pii: E1903(1-29). 2017 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  6. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Pei-Yu Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang (co-corresponding author) and Kwang-Huei Lin Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214 Sci. Rep. 7(1):14868. 2017 (SCI; IF: 4.38, 17/72=23.6%, multidisciplinary sciences)
  7. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen and K-H Lin (corresponding author) Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma Hepatology 67(1):188-203. 2018 (SCI; IF:17.425, 6/92=6.5%, Gastroenterology & Hepatology)
  8. Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung , Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi , Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin (corresponding author) Stimulation of interferon-stimulated gene 20 by thyroid hormone enhances angiogenesis in liver cancer Neoplasia 20(1):57-68. 2018 (SCI; IF:5.715, 72/242=29.8%, Oncology)
  9. Chung-Ying Tsai, Hsiang-Cheng Chi, Lang-Ming Chi, Huang-Yu Yang, Ming-Ming Tsai, Kam-Fai Lee, Hsiang-Wei Huang, Li-Fang Chou, Ann-Joy Cheng, Chih-Wei Yang, Chia-Siu Wang8 and Kwang-Huei Lin (corresponding author) Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy FASEB J. 32(5), 2601-2614, 2018 (SCI; IF:5.192, 77/195=3.95%, Cell Biology)
  10. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin (corresponding author) The impact of DNA and RNA methylation on radiobiology and cancer progression Int. J. Mol. Sci. 19, 555; doi:10.3390/ijms19020555, 2018 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  11. Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen and Kwang-Huei Lin (corresponding author) The long non-coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma Int. J. Mol. Sci. 19, 1463; doi:10.3390/ijms19051463 2018 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  12. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Hsiang-Cheng Chi, Chung-Ying Tsai, Wen-Yu Chuang, I-Hsiao Chung, Ching-Ying Chen, Chia-Jung Yu, and Kwang-Huei Lin Thyroid hormone negatively regulates tumorigenicity and self-renewal of tumor-initiating cells through suppression of BC200 Endocrine-Related Cancer 25 (12), 967-979, 2018 (SCI; IF: 5.678, 30/146=20.5%, Endocrinology & Metabolism)
  13. Yang-Hsiang Lin, Meng-Han Wu, Chau-Ting Yeh, and Kwang-Huei Lin Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication Int. J. Mol. Sci. 19 (12). pii: E3742. doi: 10.3390/ijms19123742. 2018 Nov (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  14. Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY, Lin KH. Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer. Theranostics 9(8), 2361-2379, 2019 (SCI; IF:11.556, 9/140=6.4%, Medicine, Resarch & Experimental)
  15. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, and Kwang-Huei Lin Molecular functions and clinical impact of thyroid hormone- triggered autophagy in liver-related diseases J Biomed. Sci. 26(1), 24. doi: 10.1186/s12929-019-0517-x. 2019 (SCI, IF:8.41, 15/140=10.7% Medicine, Research & Experimental)
  16. Yu-Chin Liu, Chau-Ting Yeh and Kwang-Huei Lin Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis Int. J. Mol. Sci. 20(20). 4986. ;  doi:10.3390/ijms20204986. 2019 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  17. Kam-Fai Lee , Ming-Ming Tsai , Chung-Ying Tsai , Chung-Guei Huang , Yu-Hsiang Ou ,Ching-Chuan Hsieh, Hsi-Lung Hsieh, Chia-Siu Wang , and Kwang-Huei Lin DEK is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma Int. J. Mol. Sci. 20(22), 5689; doi:10.3390/ijms20225689. 2019 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  18. Po-Shuan Huang , Chia-Siu Wang, Chau-Ting Yeh and Kwang-Huei Lin Roles of thyroid hormone-associated microRNAs affecting oxidative stress in human hepatocellular carcinoma Int. J. Mol. Sci. 20(20). 5220. ; doi:10.3390/ijms20205220. 2019 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  19. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh and Kwang-Huei Lin TUG1 is a regulator of AFP and serves as prognostic marker in non-hepatitis B non-hepatitis C hepatocellular carcinoma Cells. 9(2), 2020. (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)
  20. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Dysregulated FAM215A stimulates LAMP2 expression to confer drug-resistant and malignant in human liver cancer Cells. 9, 961, 2020. (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)
  21. Yu-Chin Liu, Chau-Ting Yeh, and Kwang-Huei Lin Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies Cells. 9(6):1331. doi: 10.3390/cells9061331. 2020 (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)
  22. Cheng-Heng Wu, Cheng-Yi Chen , Chau-Ting Yeh and Kwang-Huei Lin Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA Int. J. Mol. Sci. 9; 21. doi: 10.3390/ijms21051859. 2020 (SCI; IF: 5.924, 67/295=22.6 %, Biochemistry & Molecular Biology)
  23. Cheng-Heng Wu, Chau-Ting Yeh and Kwang-Huei Lin Thyroid hormone suppresses FOXM1 expression to reduce liver cancer progression Oncology Reports 44, 1686-1698, 2020 (SCI; IF: 3.906, 134/242=55.4 %, Oncology)
  24. Hsiang-Cheng Chi, Chung-Ying Tsai, Chia-Siu Wang, Huang-Yu Yang, Chien-Hui Lo, Won-Jing Wang, Kam-Fai Lee, Li-Yin Lai, Ji-Hong Hong, Yen-Fang Chang, Ming-Ming Tsai, Chau-Ting Yeh, Cheng Heng Wu, Ching-Chuan Hsieh, Lu-Hai Wang, Wei-Jan Chen, Kwang-Huei Lin DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell trait Oncogene 39 (37):5933-5949. 2020 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)
  25. Huang PS, Chang CC, Wang CS, Kwang-Huei Lin Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer. Biomed J. (20)30143-30148. 2020 (SCI; IF: 4.910, 108/311=34.7 %, Biochemistry & Molecular Biology)
  26. Hsiang-Wei Huang, Cheng-Chih Chang , Chia-Siu Wang and Kwang-Huei Lin. Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development Cells. 10:67. 2021 (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)
  27. Yang-Hsiang Lin, Meng-Han Wu, Yi-Chung Liu, Ping-Chiang Lyu, Chau-Ting Yeh, and Kwang-Huei Lin LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing Oncogene 40:4675–4685 2021 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)
  28. Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, and Kwang-Huei Lin Functional and clinical significance of dysregulated microRNAs in liver cancer Cancers 13, 5361, 1-24, 2021 (SCI; IF: 6.639, 51/242=21.1 %, Oncology)
  29. Hsiang-Wei Huang, Ching-Ying Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang, Cheng-Chih Chang, and Kwang-Huei Lin CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer Oncogene 41(2):159-172. 2022. (SCI; IF: 8.756, 25/321=7.79%, Biochemistry & Molecular biology)

  1. Chia-Jung Liao, Po-Shuan Huang, Hui-Tzu Chien, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease Biomedicines 10, 1232, 1-17, 2022 https://doi.org/10.3390/biomedicines10061232 (SCI; IF: 4.757,72/195=36.9%, Medicine, Research & Experimental)

  1. Pei‑Yi Chu, Wei‑Chieh Huang, Shiao‑Lin Tung, Chung‑Ying Tsai, Chih Jung Chen,Yu‑Chin Liu Chia‑Wen Lee, Yang‑Hsiang Lin, Hung‑Yu Lin, Cheng‑Yi Chen, Chau‑Ting Yeh, Kwang‑Huei Lin, and Hsiang‑Cheng Chi IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c‑MYC axis Cell & Bioscience 12:124-140, 2022 (SCI; IF: 9.606, 54/321=16.7% Biochemistry & Molecular biology)

  1. Yu-Chin Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Po-Shuan Huang, Chia-Jung Liao, Yu-Syuan Liou, Chiao-Chun Lin, Chia-Jung Yu, Chau-Ting Yeh, Ya-Hui Huang, and Kwang-Huei Lin CRNDE acts as an epigenetic modulator of the p300/YY1 complex to promote HCC progression and therapeutic resistance Clinical Epigenetics 14:106, 1-19. 2022 https://doi.org/10.1186/s13148-022-01326-3 (SCI; IF: 7.291, 19/175=10.9% Genetics & Heredity)

  1. Yang-Hsiang Lin, Yu-Chin Liu, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Po-Shuan Huang, Cheng-Chih Chang, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin LPAL2 suppresses tumor growth and metastasis of hepatocellular carcinoma by modulating MMP9 expression Cells 11:2610,1-12, 2022. https://doi.org/10.3390/ cells11162610 (SCI; IF: 7.666, 51/194=26.2 %, Cell Biology)
         

 

 

 

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