Chia-Jung Yu

Appointment: Professor

Lab：Functional Proteomics Laboratory

Education: Ph.D.

University/Nation：National Taiwan University/ Taiwan

Tel: +886-3-211-8800 ext.3424

E-mail : yucj1124@mail.cgu.edu.tw

Research website :  http://d000003200.wixsite.com/yu-cj

Research interests:

1.  Development of biomarkers for lung adenocarcinoma by proteomic approaches.

2.  Mechanistic study of biomarkers in lung cancer.

3.  Characterization of human Arl1 protein complexes functioning in vesicle trafficking.

Publications: (*, Corresponding author)

1. Lin MC, Yu CJ, Lee FJ*. Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. Proc. Natl. Acad. Sci. U S A. 2022 Jul 26;119(30):e2207414119. doi: 10.1073/pnas.2207414119. Epub 2022 Jul 20.
2. Wang YH, Chiu WY, Chen YT, Cai PJ, Wu YC, Wu JL, Chen BH, Liu YW, Yu CJ, Lee FJ*. Golgin Imh1 and GARP complex cooperate to restore the impaired SNARE recycling transport induced by ER stress. Cell Rep. 2022 Mar 22;38(12):110488. doi: 10.1016/j.celrep.2022.110488.
3. Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ*. Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma. Cancer Sci. 2022 Jan;113(1):205-220. doi: 10.1111/cas.15197. Epub 2021 Nov 25.
4. Feng HP, Cheng HY, TF Hsiao, Lin TW, Hsu JW, Huang LH, Yu CJ*. ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein. FASEB J. 2021 Apr;35(4):e21337. doi: 10.1096/fj.202000818RR.
5. Ho ML, Kuo WK, Chu LJ, Yeh IH, Fan CW, Chang HI, Yuan CL, Chou TY, Chen HY, Yang SW, Chang LC, Luo M, Wu TH, Chang YI, Yu CJ, Hua CC*, Ng WV*. N-acetylgalactosamine-6-sulfatase (GALNS), Similar to Glycodelin, Is a Potential General Biomarker for Multiple Malignancies. Anticancer Res. 2019 Nov;39(11):6317-6324. 
6. Chen YC, Jiang PH, Chen HM, Chen CH, Wang YT, Chen YJ, Yu CJ, Teng SC*. Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife. 2018 Dec 5;7. pii: e39925. doi: 10.7554/eLife.39925. 
7. Lin YH, Wu MH, Huang YH, Yeh CT, Chi HC, Tsai CY, Chuang WY, Yu CJ, Chung IH, Chen CY, Lin KH. Thyroid hormone negatively regulates tumorigenesis through suppression of BC200. Endocr. Relat. Cancer. 2018 Dec 1;25(12):967-979. doi:10.1530/ERC-18-0176. 
8. Hsu RM, Zhong CY, Wang CL, Liao WC, Yang C, Lin SY, Lin JW, Cheng HY, Li PY, Yu CJ*. Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness by modulating NF-κB activity. Cell Commun Signal. 2018 Apr 27;16(1):19. doi: 10.1186/s12964-018-0230-5.
9. Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP*. Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer. Head Neck. 2018 Mar 15. doi: 10.1002/hed.25145.  (equal to first author) 
10. Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC*. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic Acids Res. 2017 Oct 13;45(18):10492-10503. doi: 10.1093/nar/gkx683. 
11. Yang CW, Tseng SF, Yu CJ, Chung CY, Chang CY, Pobiega S, Teng SC*. Telomere shortening triggers a feedback loop to enhance end protection. Nucleic Acids Res. 2017 Aug 21;45(14):8314-8328. doi: 10.1093/nar/gkx503.
12. Yu CJ, Lee FJ*. Multiple activities of Arl1 GTPase in the trans-Golgi network. J. Cell Sci. 2017 May 15;130(10):1691-1699.
13. Tsai CH, Chen YJ, Yu CJ, Tzeng SR, Wu IC, Kuo WH, Lin MC, Chan NL, Wu KJ, Teng SC*. SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and  Cancer Proliferation. Cancer Res. 2016 Oct 15;76(20):6043-6053. 
14. Hsu CH, Hsu CW, Hsueh C, Wang CL, Wu YC, Wu CC, Liu CC, Yu JS, Chang YS, Yu CJ*. Identification and characterization of potential biomarkers by quantitative tissue proteomics of primary lung adenocarcinoma. Mol. Cell. Proteomics 2016 Jul;15(7):2396-410 .
15. Wang CI, ChenYY, Wang CL, Yu JS, Chang YS, Yu CJ*. mTOR regulates proteasomal degradation and Dp1/E2F1-mediated transcription of KPNA2 in lung cancer cells. Oncotarget 2016 May 3;7(18):25432-42. 
16. Hsu JW, Tang PH, Wang IH, Liu CL, Chen WH, Tsai PC, Chen KY, Chen KJ, Yu CJ, Lee FJ*. Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p. Proc.      Natl. Acad. Sci. U S A., 2016 Mar 22;113(12):E1683-90. 
17. Shih CL, Chong KY, Hsu SC, Chien HJ, Ma CT, Chang JW, Yu CJ*, Chiou CC*. Development of a magnetic bead-based method for the collection of circulating extracellular vesicles. N. Biotechnol. 2016 Jan 25;33(1):116-22.