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Dr. Chia-Jung Yu

Chia-Jung Yu

Appointment: Associate Professor

LabFunctional Proteomics Laboratory

Education: Ph.D.

University/NationNational Taiwan University/ Taiwan

Tel: +886-3-211-8800 ext.3424

E-mail : yucj1124@mail.cgu.edu.tw

Research website :  http://d000003200.wixsite.com/yu-cj

Research interests:

1.  Development of biomarkers for lung adenocarcinoma by proteomic approaches.

2.  Mechanistic study of biomarkers in lung cancer.

3.  Characterization of human Arl1 protein complexes functioning in vesicle trafficking.

Publications: (*, Corresponding author)

1.        Tsai CH, Chen YJ, Yu CJ, Tzeng SR, Wu IC, Kuo WH, Lin MC, Chan NL, Wu KJ, Teng SC. SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation. Cancer Res. 2016 Aug 28. pii: canres.0500.2016. [PubMed]

2.        Hsu CH, Hsu CW, Hsueh C, Wang CL, Wu YC, Wu CC, Liu CC, Yu JS, Chang YS, Yu CJ*. Identification and characterization of potential biomarkers by quantitative tissue proteomics of primary lung adenocarcinoma. Mol. Cell. Proteomics 2016 Jul;15(7):2396-410 .[PubMed]

3.        Wang CI, ChenYY, Wang CL, Yu JS, Chang YS, Yu CJ*. mTOR regulates proteasomal degradation and Dp1/E2F1-mediated transcription of KPNA2 in lung cancer cells. Oncotarget 2016 May 3;7(18):25432-42. [PubMed]

4.        Hsu JW, Tang PH, Wang IH, Liu CL, Chen WH, Tsai PC, Chen KY, Chen KJ, Yu CJ, Lee FJ*. Unfolded protein response regulates yeast Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p. Proc. Natl. Acad. Sci. U S A., 2016 Mar 22;113(12):E1683-90. [PubMed]

5.        Shih CL, Chong KY, Hsu SC, Chien HJ, Ma CT, Chang JW, Yu CJ*, Chiou CC*. Development of a magnetic bead-based method for the collection of circulating extracellular vesicles. N. Biotechnol. 2016 Jan 25;33(1):116-22. 

6.        Liu PJ, Chen C, Wang CL, Wu YC, Hsu CW, Lee CW, Huang LH, Yu JS, Chang YS, Wu CC*, Yu CJ*.In-depth proteomic analysis of six types of exudative pleural effusions for non-small cell lung cancer biomarker discovery.  Mol. Cell. Proteomics 2015 Apr;14(4):917-32. [PubMed]

7.        Wang CI, Wang CL, Wu YC, Feng HP, Liu PJ, Chang YS, Yu JS, Yu CJ*. Quantitative proteomics reveals a novel role of karyopherin alpha 2 (KPNA2) in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer. J. Proteome Res.  2015 Apr 3;14(4):1739-51. [PubMed]

8.        Lee CW, Chang KP, Chen YY, Liang Y, Hsueh C, Yu JS, Chang YS, Yu CJ*. Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness. Oncotarget 2015 Sep 8;6(26):21979-92.  [PubMed]

9.        Huang LH, Lee WC, You ST, Cheng CC, Yu CJ*. Arfaptin-1 negatively regulates Arl1-mediated retrograde transport. PLoS One 2015 Mar 19;10(3):e0118743. [PubMed]

10.    Shih CL, Luo JD, Chang JW, Chen TL, Chien YT, Yu CJ*, Chiou CC*. Circulating messenger RNA profiling with microarray and next-generation sequencing: cross-platform comparison. Cancer Genomics Proteomics 2015 09-10;12(5):223-230. [PubMed]

11.    Yu CJ*, Ko CJ, Hsieh CH, Chien CT, Huang LH, Lee CW, Jiang CC*. Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress. J. Proteomics 2014 Mar 17;99:40-53. [PubMed] 

12.    Chang SW, Fann CS, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh AR, Chien RN, Chu CM, Tai DI*. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. PLoS One 2014 Jun 18;9(6):e99724. [PubMed]

13.    Chen CD, Wang CL, Yu CJ, Chien KY, Chen YT, Chen MC, Chang YS, Wu CC, Yu JS. Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion. J Proteome Res. 2014 Jun 6;13(6):2818-29. [PubMed]

14.    Wang CI, Chien KY, Wang CL, Chang YS, Yu JS, Yu CJ*. Quantitative proteomics reveals regulation of KPNA2 and its potential novel cargo protein in non-small cell lung cancer. Mol. Cell. Proteomics 2012 Nov;11(11):1105-22. [PubMed]

15.    Yu CJ*, Wang CL, Wang CI, Chen CD, Dan YM, Wu CC, Wu YC, Lee IN, Tsai YH, Chang YS, Yu JS. Comprehensive proteome analysis of malignant pleural effusion for lung cancer biomarker discovery by using multidimensional protein identification technology. J. Proteome Res. 2011 Oct 7;10(10):4671-82. [PubMed]

16.    Yu CJ, Chang KP, Chang YJ, Hsu CW, Liang Y, Yu JS, Chi LM, Chang YS, Wu CC*. Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using Omics-based analysis. J. Proteome Res. 2011 Aug 5;10(8):3778-88. [PubMed]

17.    Wang CI, Wang CL, Wang CW, Chen CD, Wu CC, Tsai YH, Chang YS, Yu JS, Yu CJ*.  Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int. J. Cancer. 2011 May 15;128(10):2364-72. [PubMed]

18.    Wu CC, Hsu CW, Chen CD, Yu CJ, Chang KP, Dai DI, Liu HP, Su WH, Chang YS, Yu JS*. Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol. Cell. Proteomics 2010 Jun;9 (6):1100-17. [PubMed]

19.    Chen KY, Tsai PC, Hsu JW, Hsu HC, Fang CY, Chang LC, Tsai YT, Yu CJ, Lee FJ*. Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p. J. Cell Sci. 2010 Sep;14(123): 3478-3489. [PubMed]

20.    Wang CL, Wang CI, Liao PC, Chen CD, Liang Y, Chuang WY, Tsai YH, Chen HC, Chang YS, Yu JS, Wu CC*, Yu CJ*. Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome. J. Proteome Res. 2009 Oct 2;8(10):4428-4440. [PubMed] 

21.    Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, Tang P, See LC, Hsueh C, Yang ML, Hao SP, Li HY, Wang MH, Liao LP, Chen LC, Lin SR, Jorgensen TJ, Chang YS*, Shugart YY. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. Am. J. Hum. Genet. 2009 Aug;85(2):194-203. [PubMed] 

22.    Chi LM, Lee CW, Chang KP, Hao SP, Lee HM, Liang Y, Hsueh C, Yu CJ, Lee IN, Chang YJ, Lee SY, Yeh YM, Chang YS, Chien KY*, Yu JS*. Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated two-dimensional LC-ESI-MALDI tandem MS. Mol. Cell. Proteomics 2009 Jul; 8(7):1453-74. [PubMed]

23.    Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC*, Chien CT*, Chen CF. Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. J. Biomed. Sci. 2009 Mar 25; 16(1):35. [PubMed] 

24.    Cheng WL, Wang CS, Huang YH, Liang Y, Lin PY, Hsueh C, Wu YC, Chen WJ, Yu CJ, Lin SR, Lin KH*. Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. Int. J. Cancer. 2008 Oct 15;123(8):1787-96. [PubMed]

25.    Wu CC, Chen HC, Chen SJ, Liu HP, Hsieh YY, Yu CJ, Tang R, Hsieh LL, Yu JS*, Chang YS Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes. Proteomics 2008 Jan; 8(2): 316-32. [PubMed]

26.    Yu CJ, Chen YC, Hsiao CH, Kuo TC, Chang SC, Lu CY, Wei WC, Lee CH, Huang LM, Chang MF, Ho HN, Lee FJ*. Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus. FEBS Lett. 2004 May 7; 565(1-3):111-6. [PubMed]

27.    Yu CJ, Lin YF, Chiang BL, Chow LP*. Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J. Immunol. 2003 Jan 1; 170(1):445-53. [PubMed]

28.    Yu CJ, Chen YM, Su SN, Forouhar F, Lee SH, Chow LP*. Molecular and immunological characterization and IgE epitope mapping of Pen n 18, a major allergen of Penicillium notatum. Biochem. J. 2002 May 1; 363(Pt 3):707-15. [PubMed]

29.    Chern CL, Yu CJ, Tsai CH, Liu TZ*. (2001) Periodate-catalyzed oxidative coupling of aniline-derived p-aminophenol with p-xylenol as a detection method for hydroxyl radicals. Anal. Lett. 34: 2477-2484 . [PubMed]

30.    Chow LP*, Liu SL, Yu CJ, Liao HK, Tsai JJ, Tang TK. Identification and expression of an allergen Asp f 13 from A. fumigatus and epitope mapping using human IgE antibodies and rabbit polyclonal antibodies. Biochem. J. 2000 Mar 1; 346 Pt 2:423-31. [PubMed]

31.    Chow LP*, Chiou SH, Hsiao MC, Yu CJ, Chiang BL. Characterization of Pen n 13, a major allergen from the mold Penicillium notatum. Biochem. Biophys. Res. Commun. 2000 Mar 5;269(1):14-20. [PubMed]

32.    Yu CJ, Chiou SH, Lai WY, Chiang BL, Chow LP*. Characterization of a novel allergen, a major IgE-binding protein from Aspergillus flavus, as an alkaline serine protease. Biochem. Biophys. Res. Commun. 1999 Aug 11; 261(3):669-75. [PubMed]

33.    Chow LP*, Su NY, Yu CJ, Chiang BL, Shen HD. Identification and expression of Pen c 2, a novel allergen from the Penicillium citrinum. Biochem. J. 1999 Jul 1; 341 (Pt 1):51-9. [PubMed] 

34.    Su NY, Yu CJ, Shen HD, Pan FM, Chow LP*. Pen c 1, a novel enzymic allergen protein from Penicillium citrinum. Purification, characterization, cloning and expression. Eur. J. Biochem. 1999 Apr; 261(1):115-23. [PubMed]

35.    Kao JT*, Hsiao WH, Yu CJ, Chiang FT. Newly identified missense mutation reduces lipoprotein lipase activity in Taiwanese patients with hypertriglyceridemia. J. Formos. Med. Assoc. 1999 Sep; 98(9):606-12. [PubMed]





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