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Dr. Kwang-Huei Lin

 

Kwang-Huei Lin

Appointment : Professor/Associate Dean College of Medicine

LabGene Regulation

Education : Ph.D.

University/NationAlabama/USA

Tel:  88632118800 ext.5975

E-mail : khlin@mail.cgu.edu.tw

Research website : http://lncrna103.wixsite.com/cgu-lkh

Research interests:

A.   The role of thyroid hormone during liver carcinogenesis.

B.   The mechanism of genes including miRNAs, long non-coding (Lnc)RNAs regulated by thyroid hormone during cell proliferation, differentiation and /or tumorigenesis. The genomic or proteomic approaches will be applied.

C.   The identification of cancer biomarkers including miRNAs, LncRNAs in liver, gastric, cervical, skin cancer and glioma by genomic or proteomic approaches.

D.   The mechanism of autophagy regulated by thyroid hormone.

E.   The role and regulation of LncRNAs in tumor.

 

                

 

Awards in the past five years
1. Outstanding Research Award of the Ministry of Science and    Technology (2017)
2. Distinguished Professor of Chang Gung University (2015-present)
3. Excellent Teacher Research Award of Chang Gung University (2005, 2012, 2017, 2018, 2019)
4. Best Paper of Liver Disease Prevention Foundation (2013, 2015, 2017)
5. The 28th (2018) Wang Minning Award-Basic Medicine-Outstanding  Contribution Award

2014-2020 published papers(May 2020 updated, selective, all corresponding authors)

  1. Yi-Hsin Tseng, Po-Yuan Ke, Chia-Jung Liao, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Cheng-Yi Chen, Yang-Hsiang Lin, and K-H Lin (corresponding author) Chromosome 19 Open Reading Frame 80 Is Upregulated by the Thyroid Hormone and Modulates Autophagy and Lipid Metabolism Autophagy 10(1), 20-31, 2014 (SCI; IF: 11.059 , 14/193=7.3%, Cell Biology)
  2. Chung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai, Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng, Cheng-Yi Chen, Crystal D. Lin, Jun-I Wu, Lu-Hai Wang, and K-H Lin (corresponding author) Interleukin 32 Increases Human Gastric Cancer cell invasion Associated with Tumor Progression and Metastasis Clinical Cancer Re. 20(9), 2276-88, 2014 (SCI; IF: 8.911, 16/229=7% Oncology)
  3. Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai4 and K-H Lin (corresponding author) Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling Mol. Cancer 13(1), 162, 2014 (SCI; IF: 10.679, 11/229=4.8%, Oncology)
  4. Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh and K-H Lin (corresponding author) Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line BMC Cancer 14(1), 555, 2014 (SCI; IF: 2.933, 121/229=52.8% Oncology)
  5. Tsai MM, Wang CS, Tsai CY, Chi HC, Tseng YH, K-H Lin (corresponding author) Potential prognostic, diagnostic and therapeutic markers for human gastric cancer. World J Gastroenterol. 20(38), 13791-13803, 2014 (review; SCI; IF: 3.411, 35/84=41.7% Gastroenterology & Hepatology)
  6. Y-H Tseng, Y-H Yeh, W-J Chen, and K-H Lin (corresponding author) Emerging Regulation and Function of Betatrophin Int. J. Mol. Sci. 15(12), 23640-23657, 2014 (review; SCI; IF: 4.183, 78/298=26.2%, Biochemistry & Molecular Biology)
  7. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-ling Lin, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yeh and K-H Lin (corresponding author) Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth Inter. J. Cancer 137(1), 37-49, 2015 (SCI; IF: 4.982, 51/229=22.3%, Oncology)
  8. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai, Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh, Wei-Jan Chen and K-H Lin (corresponding author) Repression of microRNA-130b by thyroid hormone enhances cell motility J Hepatology 62(6), 1328-1340, 2015 (SCI; IF: 18.946, 3/84=3.6%, Gastroenterology & Hepatology)
  9. Cheng-Yi Chen, Chie-Pein Chen, and K-H Lin Biological Functions of Thyroid Hormone in Placenta Int. J. Mol. Sci.16(2), 4161-4179, 2015 (review; SCI; IF: 4.183, 78/298=26.2%, Biochemistry & Molecular Biology)
  10. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author) Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer Int. J. Mol. Sci., 17(6), doi:10.3390/ijms17060945, 2016 (review; SCI; IF: 4.183, 78/298=26.2%, Biochemistry & Molecular Biology)
  11. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author)  Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer Eur. J Cancer 64,137-148, 2016 (SCI; IF: 6.68, 26/229=11.4%, Oncology)
  12. Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1 dependent selective Autophagy 12(12), 2271-2285, 2016 (SCI; IF: 11.059 , 14/193=7.3%, Cell Biology)
  13. Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang and K-H Lin (corresponding author)  Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway Cell Death & Disease 7, e2324, 2016 (SCI; IF: 5.959, 38/193=19.7% Cell Biology)
  14. Tseng YH, Huang YH, Lin TK, Wu SM, Chi HC, Tsai CY, Tsai MM, Lin YH, Chang WC, Chang YT, Chen WJ, and K-H Lin (corresponding author) Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma Sci Rep. 6:38756. doi: 10.1038/srep38756, 2016 (SCI; IF: 4.011, 15/69=21.7%, multidisciplinary sciences)
  15. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, … Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author)  Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression Int. J. Cancer 140(7), 1581-1596. 2017 (SCI; IF: 4.982, 51/229=22.3%, Oncology)
  16. I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh and K-H Lin (corresponding author) The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma Sci Rep. 7:295 doi: 10.1038/s41598-017-00382-7, 2017 (SCI; IF: 4.011, 15/69=21.7%)
  17. Hsiang-Cheng Chi, Shen-Liang Chen, Syuan-Ling Lin, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone protect hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover Oncogene 36(37), 5274-5284, 2017 (SCI; IF: 6.634, 28/229=12.2%, Oncology)
  18. Tzu-Kang Lin, Chang-Nen Chang, Cheng-Shian Tsai, Yin-Cheng Huang, Yu-Jen Lu, Wei-Jan Chen, Yang-Hsiang Lin, I-Hsiao Chung and K-H Lin (corresponding author) The long non-coding RNA LOC441204 enhances cell growth in human glioma Scientific Reports 7(1):5603. 2017 (SCI; IF: 4.011, 15/69=21.7%, multidisciplinary sciences)
  19. Hsiang-Cheng Chi , Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin  Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells Int. J. Mol. Sci. 18(9). pii: E1903(1-29). 2017 (review; IF: 4.183, 78/298=26.2%, Biochemistry & Molecular Biology)
  1. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Pei-Yu Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang (co-corresponding author) and Kwang-Huei Lin Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214 Sci Rep. 7(1):14868. 2017 Nov 1 (SCI; IF: 4.011, 15/69=21.7%, multidisciplinary sciences)
  2. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen and K-H Lin (corresponding author) Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma Hepatology 67(1):188-203. 2018 (SCI; IF:14.971, 5/84=5.95%, Gastroenterology & Hepatology)
  3. Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung , Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi , Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin (corresponding author) Stimulation of interferon-stimulated gene 20 by thyroid hormone enhances angiogenesis in liver cancer Neoplasia 20(1):57-68. 2018 (SCI; IF:3.837, 76/229=33.2%, Oncology )
  4. Chung-Ying Tsai, Hsiang-Cheng Chi, Lang-Ming Chi, Huang-Yu Yang, Ming-Ming Tsai, Kam-Fai Lee, Hsiang-Wei Huang, Li-Fang Chou, Ann-Joy Cheng, Chih-Wei Yang, Chia-Siu Wang8 and Kwang-Huei Lin (corresponding author) Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy FASEB J. 32(5), 2601-2614, 2018 (SCI; IF:5.391, 8/87=9.2%, Biology)
  5. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin (corresponding author) The impact of DNA and RNA methylation on radiobiology and cancer progression Int. J. Mol. Sci. 19, 555; doi:10.3390/ijms19020555, 2018 (Review; SCI; IF: 4.183, 78/299=26.1%, Biochemistry & Molecular Biology)
  6. Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen and Kwang-Huei Lin (corresponding author) The long non-coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma Int. J. Mol. Sci. 19, 1463; doi:10.3390/ijms19051463 2018 (SCI; IF: 4.183, 78/299=26.1%, Biochemistry & Molecular Biology)
  7. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Hsiang-Cheng Chi, Chung-Ying Tsai, Wen-Yu Chuang, I-Hsiao Chung, Ching-Ying Chen, Chia-Jung Yu, and Kwang-Huei Lin Thyroid hormone negatively regulates tumorigenicity and self-renewal of tumor-initiating cells through suppression of BC200 Endocrine- Related Cancer 25 (12), 967-979, 2018 (SCI; IF: 4.774, 27/145=18.6%, Endocrinology & Metabolism)
  8. Yang-Hsiang Lin, Meng-Han Wu, Chau-Ting Yeh, and Kwang-Huei Lin Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication Int. J. Mol. Sci. 19 (12). pii: E3742. doi: 10.3390/ijms19123742. 2018 Nov (Review; SCI; IF: 4.183, 78/299=26.1%, Biochemistry & Molecular Biology)
  9. Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY, Lin KH. Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer. Theranostics 9(8), 2361-2379, 2019 (SCI; IF:8.063, 10/136=7.4%, Medicine, Resarch & Experimental)
  10. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, and Kwang-Huei Lin Molecular functions and clinical impact of thyroid hormone- triggered autophagy in liver-related diseases J Biomed. Sci. 26(1), 24. doi: 10.1186/s12929-019-0517-x. 2019 (SCI, IF:5.203, 20/136=14.7% Medicine, Research & Experimental)
  11. Yu-Chin Liu, Chau-Ting Yeh and Kwang-Huei Lin Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis Int. J. Mol. Sci. 20(20). 4986. ;  doi:10.3390/ijms20204986. 2019 (SCI; IF: 4.183, 78/299=26.1 %, Biochemistry & Molecular Biology)
  12. Kam-Fai Lee , Ming-Ming Tsai , Chung-Ying Tsai , Chung-Guei Huang , Yu-Hsiang Ou ,Ching-Chuan Hsieh, Hsi-Lung Hsieh, Chia-Siu Wang , and Kwang-Huei Lin DEK is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma Int. J. Mol. Sci. 20(22), 5689; doi:10.3390/ijms20225689. 2019 (SCI; IF: 4.183, 78/299=26.1 %, Biochemistry & Molecular Biology)
  13. Po-Shuan Huang , Chia-Siu Wang, Chau-Ting Yeh and Kwang-Huei Lin Roles of thyroid hormone-associated microRNAs affecting oxidative stress in human hepatocellular carcinoma Int. J. Mol. Sci. 20(20). 5220. ; doi:10.3390/ijms20205220. 2019 (SCI; IF: 4.183, 78/299=26.1 %, Biochemistry & Molecular Biology)
  14. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh and Kwang-Huei Lin TUG1 is a regulator of AFP and serves as prognostic marker in non-hepatitis B non-hepatitis C hepatocellular carcinoma Cells. 9(2), 2020.  (SCI; IF: 5.656, 40/193=20.7 %, Cell Biology)
  15. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Dysregulated FAM215A stimulates LAMP2 expression to confer drug-resistant and malignant in human liver cancer Cells. 9, 961, 2020.  (SCI; IF: 5.656, 40/193=20.7 %, Cell Biology)

 

 

 

 

 

 

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