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Dr. Kwang-Huei Lin

 

Kwang-Huei Lin

Appointment : Professor/Associate Dean College of Medicine

LabGene Regulation

Education : Ph.D.

University/NationAlabama/USA

Tel:  88632118800 ext.5975

E-mail : khlin@mail.cgu.edu.tw

Research website : http://lncrna103.wixsite.com/cgu-lkh

Research interests:

A.   The role of thyroid hormone during liver carcinogenesis.

B.   The mechanism of genes including miRNAs, long non-coding (Lnc)RNAs regulated by thyroid hormone during cell proliferation, differentiation and /or tumorigenesis. The genomic or proteomic approaches will be applied.

C.   The identification of cancer biomarkers including miRNAs, LncRNAs in liver, gastric, cervical, skin cancer and glioma by genomic or proteomic approaches.

D.   The mechanism of autophagy regulated by thyroid hormone.

E.   The role and regulation of LncRNAs in tumor.

 

               The role and regulation of LncRNAs in tumor. Update2022/08/02

 

Awards in the past five years
1. Outstanding Research Award of the Ministry of Science and Technology (2017)
2. Distinguished Professor of Chang Gung University (2015-present)
3. Excellent Teacher Research Award of Chang Gung University (2005, 2012, 2017, 2018, 2019)
4. Best Paper of Liver Disease Prevention Foundation (2013, 2015, 2017)
5. The 28th (2018) Wang Minning Award-Basic Medicine-Outstanding Contribution Award

2015-2022 Publication listed (selected publication, all corresponding author SCI papers) August 2, 2022 updated

2022

  1. Hsiang-Wei Huang, Ching-Ying Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang, Cheng-Chih Chang, and Kwang-Huei Lin CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer Oncogene 41(2):159-172. 2022. (SCI; IF:9.867, 29/295=9.8%, Biochemistry & Molecular biology)

2021

  1. Hsiang-Wei Huang, Cheng-Chih Chang, Chia-Siu Wang and Kwang-Huei Lin. Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development Cells. 10:67. 2021 (SCI; IF: 6.600, 53/195=27.2 %, Cell Biology)
  2. Yang-Hsiang Lin, Meng-Han Wu, Yi-Chung Liu, Ping-Chiang Lyu, Chau-Ting Yeh, and Kwang-Huei Lin LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing Oncogene 40:4675–4685 2021 (SCI; IF: 9.867, 29/295=9.8%, Biochemistry & Molecular biology)
  3. Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, and Kwang-Huei Lin Functional and clinical significance of dysregulated microRNAs in liver cancer Cancers 13, 5361, 1-24, 2021 (SCI; IF: 6.639, 51/242=21.1 %, Oncology)

2020

  1. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh and Kwang-Huei Lin TUG1 is a regulator of AFP and serves as prognostic marker in non-hepatitis B non-hepatitis C hepatocellular carcinoma Cells 9(2): 262. doi: 10.3390/cells9020262. 2020 Jan 21 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)
  2. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh and Kwang-Huei Lin Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer Cells 9(4):961. doi: 10.3390/cells9040961. 2020 Apr14 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)
  3. Syuan-Ling Lin, Yang-Hsiang Lin, Hsiang-Cheng Chi, Tzu-Kang Lin, Wei-Jan Chen, Chau-Ting Yeh and Kwang-Huei Lin A Novel Long Non-Coding RNA-01488 Suppressed Metastasis and Tumorigenesis by Inducing miRNAs That Reduce Vimentin Expression and Ubiquitination of Cyclin E Cells 9(6):1504. doi: 10.3390/cells9061504. 2020 Jun 20 (SCI; IF: 6.600, 70/195=35.9%, cell Biology)
  4. Yu-Chin Liu, Chau-Ting Yeh and Kwang-Huei Lin Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies Cells 9(6):1331. doi: 10.3390/cells9061331. 2020 May 26 (Review; IF: 6.600, 70/195=35.9%, cell Biology)
  5. Cheng-Heng Wu, Cheng-Yi Chen, Chau-Ting Yeh and Kwang-Huei Lin Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA International Journal of Molecular Sciences 21(5):1859. doi: 10.3390/ijms21051859. 2020 Mar 9 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)
  6. Hsiang-Cheng Chi, Chung-Ying Tsai, Chia-Siu Wang, Huang-Yu Yang, Chien-Hui Lo, Won-Jing Wang, Kam-Fai Lee, Li-Yin Lai, Ji-Hong Hong, Yen-Fang Chang, Ming-Ming Tsai, Chau-Ting Yeh, Cheng Heng Wu, Ching-Chuan Hsieh, Lu-Hai Wang, Wei-Jan Chen and Kwang-Huei Lin DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits Oncogene 39(37):5933-5949. doi: 10.1038/s41388-020-01390-0. 2020 Sep 10 (SCI; IF: 9.867, 26/244=9.8%, Oncology)
  7. Cheng-Heng Wu, Chau-Ting Yeh and Kwang-Huei Lin Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression Oncology Reports 44(4):1686-1698. doi: 10.3892/or.2020.7716 2020 Oct (SCI; IF: 3.906, 115/244=47.1%, Oncology)
  8. Huang PS, Chang CC, Wang CS, Kwang-Huei Lin Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer. Biomed J. (20)30143-30148. 2020 (SCI; IF: 4.910, 108/311=34.7 %, Biochemistry & Molecular Biology)
  9. Yu-De Chu, Wey-Ran Lin, Yang-Hsiang Lin, Wen-Hsin Kuo, Chin-Ju Tseng, Siew-Na Lim, Yen-Lin Huang, Shih-Chiang Huang, Ting-Jung Wu, Kwang-Huei Lin, Chau-Ting Yeh COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma Cancers 12(6):1646. 2020 (SCI; IF: 6.639, 51/242=21.1 %, Oncology)
  10. Yang-Hsiang Lin, Kwang-Huei Lin, Chau-Ting Yeh Thyroid Hormone in Hepatocellular Carcinoma: Cancer Risk, Growth Regulation, and Anticancer Drug Resistance Front Med 7:174. 2020 (SCI; IF: 5.093, 28/167=16.8%, Medicine, General & Internal)
  11. Chih-Lang Lin, Rong-Nan Chien, Yu-De Chu, Kung-Hao Liang, Ya-Hui Huang, Po-Yuan Ke, Kwang-Huei Lin, Yang-Hsiang Lin, Chau-Ting Yeh Hepatitis B Virus X gene mutants emerge during antiviral therapy and increase cccDNA levels to compensate for replication suppression Hepatol Int. 14(6):973-984. 2020 (SCI; IF: 6.047, 24/92=34.7 %, Gastroenterology & Hepatology)

2019

  1. Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY, Lin KH Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer Theranostics 9(8):2361-2379. doi: 10.7150/thno.29628. eCollection 2019 Apr 13 (SCI; IF:11.556, 10/136=7.4%, Medicine, Resarch & Experimental)
  2. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, and Kwang-Huei Lin Molecular functions and clinical impact of thyroid hormone- triggered autophagy in liver-related diseases Journal of Biomedical Science 26(1):24. doi: 10.1186/s12929-019-0517-x. 2019 Mar 8 (SCI, IF:8.41, 20/136=14.7% Medicine, Research & Experimental)
  3. Yu-Chin Liu, Chau-Ting Yeh, and Kwang-Huei Lin Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis International Journal of Molecular Sciences 20(20). 4986.(page 1-27) doi: 10.3390/ijms20204986. 2019 Oct 9 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)
  4. Po-Shuan Huang, Chia-Siu Wang, Chau-Ting Yeh, and Kwang-Huei Lin Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma International Journal of Molecular Sciences 20(20). 5220.(page 1-24) doi: 10.3390/ijms20205220. 2019 Oct 21 (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

2018

  1. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin The impact of DNA and RNA methylation on radiobiology and cancer progression International Journal of Molecular Sciences 19(2). pii: E555. doi: 10.3390/ijms19020555. 2018 Feb (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)
  2. Chung-Ying Tsai, Hsiang-Cheng Chi, Lang-Ming Chi, Huang-Yu Yang, Ming-Ming Tsai, Kam-Fai Lee, Hsiang-Wei Huang, Li-Fang Chou, Ann-Joy Cheng, Chih-Wei Yang, Chia-Siu Wang and Kwang-Huei Lin Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy FASEB Journal 32(5):2601-2614. doi: 10.1096/fj.201700094R. 2018 May (SCI; IF:5.192, 9/93=9.7%, Biology)
  3. Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen and Kwang-Huei Lin The long non-coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma International Journal of Molecular Sciences 19(5):1463; doi:10.3390/ijms19051463 2018 May (SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)
  4. Chen TH, Chiu CT, Lee C, Chu YY, Cheng HT, Hsu JT, Wu RC, Yeh TS, Lin KH Circulating microRNA-22-3p Predicts the Malignant Progression of Precancerous Gastric Lesions from Intestinal Metaplasia to Early Adenocarcinoma Digestive diseases and sciences 63(9) 2301–2308. doi: 10.1007/s10620-018-5106-4. 2018 Sep (SCI; IF: 2.751, 57/88=64.8%, Gastroenterology & Hepatology)
  5. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Hsiang-Cheng Chi, Chung-Ying Tsai, Wen-Yu Chuang, I-Hsiao Chung, Ching-Ying Chen, Chia-Jung Yu, and Kwang-Huei Lin Thyroid hormone negatively regulates tumorigenesis through suppression of BC200 Endocrine-Related Cancer 25 (12), 967-979, 2018 Dec (SCI; IF: 5.678, 22/124=17.7%, Endocrinology & Metabolism)
  6. Yang-Hsiang Lin, Meng-Han Wu, Chau-Ting Yeh, and Kwang-Huei Lin Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication International Journal of Molecular Sciences 19 (12). pii: E3742. doi: 10.3390/ijms19123742. 2018 Nov (Review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology)

2017

  1. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung     Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author) Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int. J. Cancer 140(7):1581-1596. 2017.  doi: 10.1002/ijc.30559. (SCI; IF: 7.396, 59/244=24.2%, Oncology)
  2. I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh and K-H Lin (corresponding author) The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. Sci Rep.  7(1), 295, 2017. doi: 10.1038/s41598-017-00382-7. (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)
  3. Hsiang-Cheng Chi, Shen-Liang Chen, Syuan-Ling Lin, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone protect hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene 36(37):5274-5284 2017 doi: 10.1038/onc.2017.136. (SCI; IF: 9.867, 26/244=9.8%, Oncology)
  4. Tzu-Kang Lin, Chang-Nen Chang, Cheng-Shian Tsai, Yin-Cheng Huang, Yu-Jen Lu, Wei-Jan Chen, Yang-Hsiang Lin, I-Hsiao Chung and K-H Lin (corresponding author) The long non-coding RNA LOC441204 enhances cell growth in human glioma. Sci Rep. 7 (1), 5603, 2017. doi: 10.1038/s41598-017-05688-0. (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)
  5. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and K-H Lin Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells. Int. J. Mol. Sci. 2017 (review; SCI; IF: 4.38, 74/297=24.9%, Biochemistry & Molecular Biology)
  6. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Pei-Yu Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang (co-corresponding author) and Kwang-Huei Lin Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214. Sci Rep. 7(1):14868. doi: 10.1038/s41598-017-14864-1. 2017 Nov 1 (SCI; IF: 4.38, 17/71=23.9%, multidisciplinary sciences)
  7. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen and Kwang-Huei Lin Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma Hepatology 67(1):188-203.  doi: 10.1002/hep.29462 2018 Jan (SCI; IF:17.425, 6/88=6.8%, Gastroenterology & Hepatology)
  8. Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung, Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Stimulation of interferon-stimulated gene 20 by thyroid hormone enhances angiogenesis in liver cancer Neoplasia 20(1):57-68.  doi: 10.1016/j.neo. 2017.10.007 2018 Jan (SCI; IF:5.715, 48/244=19.7%, Oncology)

2016

  1. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author) Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer. Int. J. Mol. Sci., 17(6), 945, 2016 (review; SCI; IF: 5.924, 74/297=24.9%, Biochemistry & Molecular Biology) 
  2. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author)  Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer. Eur. J Cancer Accepted. (SCI; IF: 9.162, 31/244=12.7%, Oncology)
  3. Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh and Kwang-Huei Lin (corresponding author) Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1 dependent selective. Autophagy 12(12): 2271-2285, 2016 (SCI; IF: 16.016, 22/195=11.3%, Cell Biology)
  4. Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang and K-H Lin (corresponding author) Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death & Disease 4;7(8):2016 (SCI; IF: 8.469, 40/195=20.5% Cell Biology)
  5. Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author) Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int. J. Cancer 2016 Dec 7. doi: 10.1002/ijc.30559. (SCI; IF:7.396, 29/213=13.6%, Oncology)
  6. Tseng YH, Huang YH, Lin TK, Wu SM, Chi HC, Tsai CY, Tsai MM, Lin YH, Chang WC, Chang YT, Chen WJ, and K-H Lin (corresponding author) Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep. 9; 6:38756. 2016. (SCI; IF:4.38, 7/63=11.1%, multidisciplinary sciences)

2015

  1. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-ling Lin, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yeh and K-H Lin (corresponding author) Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth. Inter. J. Cancer 137:37-49, 2015 (SCI; IF:7.396, 29/213=13.62%, Oncology)
  2. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai,Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh, Wei-Jan Chen and K-H Lin (corresponding author) Repression of microRNA-130b by thyroid hormone enhances cell motility. J Hepatology 62:1328-1340,2015 (SCI; IF: 25.083, 5/79=6.33% Gastroenterology & Hepatology)
  3. Cheng-Yi Chen, Chie-Pein Chen, and K-H Lin (corresponding author) Biological Functions of Thyroid Hormone in Placenta. Int. J. Mol. Sci.16(2): 4161-4179, 2015 (review; SCI; IF: 5.924, 52/163=31.90%, Chemistry, multidisciplinary)
  4. Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Ya-Hui Huang, and K-H Lin (corresponding author) A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. Oncotarget 6(11)9341-54,2015 (SCI; IF: 5.008, 36/213=16.90% , Oncology)
  5. I-Hsiao Chung, Cheng-Yi Chen, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang, Pei-Ju Tai, Chia-Jung Liao, Chung-Ying Tsai, Syuan-Ling Lin, Meng-Han Wu, Ching-Ying Chen and K-H Lin (corresponding author) Thyroid Hormone-Mediated Regulation of Lipocalin 2 through the Met/FAK Pathway in Liver Cancer. Oncotarget 6(17) 15050-64, 2015 (SCI; IF: 5.008, 36/213=16.90%, Oncology)

 

 

 

 

 

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